Travel-associated Antimicrobial Drug-Resistant Nontyphoidal Salmonellae, 2004-2009
Travel-associated Antimicrobial Drug-Resistant Nontyphoidal Salmonellae, 2004-2009
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DOI：
10.3201/eid2004.131063
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发表时间：
2014-04-01
影响因子：
11.8
通讯作者：
Cieslak, Paul R.
中科院分区：
文献类型：
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作者：
Barlow, Russell S.;DeBess, Emilio E.;Cieslak, Paul R.
为了评估获得抗菌药物耐药性非伤寒沙门氏菌感染的趋势和危险因素，我们检索了俄勒冈州 2004-2009 年所有培养确诊沙门氏菌病病例的监测数据。我们将临床重要耐药性 (CIR) 定义为对氨苄西林、头孢曲松、环丙沙星、庆大霉素或甲氧苄啶/磺胺甲恶唑的敏感性降低。在 2,153 例病例中，从特定来源（例如粪便、尿液、血液或其他正常无菌组织）获得了 2,127 株（99%）非伤寒沙门氏菌分离株，并进行了药物敏感性测试。其中，347 个（16%）分离株具有 CIR。感染 CIR 的几率逐年显着增加。与未感染 CIR 的患者相比，患有 CIR 感染的患者更有可能住院。在已接受检测的分离株患者中，我们分析了 1,813 名接受采访的患者 (84%) 的数据。前往东亚或东南亚旅行与 CIR 增加有关。与爆发相关的分离株出现 CIR 的可能性较小。未来的监视活动应评估对国际旅行的阻力。
To evaluate trends in and risk factors for acquisition of antimicrobial-drug resistant nontyphoidal Salmonella infections, we searched Oregon surveillance data for 2004-2009 for all culture-confirmed cases of salmonellosis. We defined clinically important resistance (CIR) as decreased susceptibility to ampicillin, ceftriaxone, ciprofloxacin, gentamicin, or trimethoprim/sulfamethoxazole. Of 2,153 cases, 2,127 (99%) nontyphoidal Salmonella isolates were obtained from a specific source (e.g., feces, urine, blood, or other normally sterile tissue) and had been tested for drug susceptibility. Among these, 347 (16%) isolates had CIR. The odds of acquiring CIR infection significantly increased each year. Hospitalization was more likely for patients with than without CIR infections. Among patients with isolates that had been tested, we analyzed data from 1,813 (84%) who were interviewed. Travel to eastern or Southeast Asia was associated with increased CIR. Isolates associated with outbreaks were less likely to have CIR. Future surveillance activities should evaluate resistance with respect to international travel.