Brain morphology in first-episode schizophrenia: A meta-analysis of quantitative magnetic resonance imaging studies
Brain morphology in first-episode schizophrenia: A meta-analysis of quantitative magnetic resonance imaging studies
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DOI：
10.1016/j.schres.2005.11.004
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发表时间：
2006-02-15
影响因子：
4.5
通讯作者：
Dieci, A
中科院分区：
文献类型：
--
作者：
Vita, A;De Peri, L;Dieci, A
背景：对脑结构影像学研究的多项荟萃分析综述表明，在精神分裂症中始终能发现多种细微的脑部异常。然而，迄今为止发表的定量综述主要包括对慢性精神分裂症患者进行的研究，未能提供关于首发精神分裂症中特定的、可能不同的研究结果的明确信息。
方法：我们对报告了首发精神分裂症患者和健康对照者脑区体积定量测量的磁共振成像（MRI）研究进行了系统检索。对6个脑区进行了12项荟萃分析。
结果：确定了21项适合分析的研究。结果显示，侧脑室和第三脑室体积增大，以及全脑和海马体积减小具有显著的总体效应量，但颞叶、杏仁核和颅内总体积无显著变化。
结论：现有文献数据有力地表明，首发精神分裂症患者已经存在一些脑部异常。然而，与主要针对慢性精神分裂症患者样本进行的已发表荟萃分析结果不同，本研究未证实首发精神分裂症患者颞叶或杏仁核体积显著减小。这些发现支持了在精神分裂症病程中不同脑区有不同模式或受累情况的假说。（c）2005爱思唯尔B.V.版权所有。
Background: A number of meta-analytic reviews Of Structural brain imaging studies have shown that multiple subtle brain abnormalities are consistently found in schizophrenia. However, quantitative reviews till now published have included mainly Studies performed on chronic schizophrenic patients but have failed to provide clear information on specific, possibly different, findings in first-episode schizophrenia.Methods: We performed a systematic search for MRI studies that reported quantitative measurements of volumes of brain regions in first-episode schizophrenic patients and in healthy controls. Twelve meta-analyses were performed for 6 cerebral regions.Results: Twenty-one studies were identified as suitable for analysis. Significant overall effect sizes were demonstrated for lateral and third ventricular volume increase, and for Volume reduction of whole brain and hippocampus, but not for temporal lobe, amygdala and total intracranial volumes.Conclusions: The available literature data strongly indicate that some brain abnormalities are already present in first-episode schizophrenic patients. However, unlike the results of published meta-analyses conducted primarily on samples of chronic schizophrenic patients, the present study did not confirm a significant reduction of temporal lobe or amygdala volumes in first-episode schizophrenia. These findings support the hypothesis of different patterns or involvement of various cerebral areas over the time course of schizophrenia. (c) 2005 Elsevier B.V. All rights reserved.