Autophagy in endometriosis: Friend or foe?
Autophagy in endometriosis: Friend or foe?
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DOI：
10.1016/j.bbrc.2017.10.145
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发表时间：
2018-01-01
影响因子：
3.1
通讯作者：
Wei, Bing
中科院分区：
文献类型：
--
作者：
Zhan, Lei;Li, Jun;Wei, Bing
子宫内膜异位症是一种慢性、雌激素依赖性疾病，其特征是子宫内膜腺体和间质深而随意地植入子宫腔外。估计有10%的育龄妇女受其影响，导致与健康有关的生活质量明显下降。子宫内膜异位症的病因有哪些？此外，子宫内膜异位症早期诊断困难，治疗方法有限。重要的是，新出现的证据已经调查了子宫内膜异位症和自噬之间的密切关系。然而，自噬在子宫内膜异位症中是敌是友仍是一个谜，自噬在子宫内膜异位症中的确切机制尚未完全阐明。在这里，我们提供了一个关于子宫内膜异位症和自噬之间的联系的获得性发现的综合观点。我们还讨论了子宫内膜异位症自噬异常的原因。(C)2017爱思唯尔公司All rights reserved.
Endometriosis is a chronic, estrogen-dependent disease and characterized by the implantation of endometrial glands and stroma deep and haphazardly into the outside the uterine cavity. It affects an estimated 10% of the female population of reproductive age and results in obvious reduction in health related quality of life. Unfortunately, there is no a consistent theory for the etiology of endometriosis. Furthermore, the endometriosis is hard to diagnose in early stage and the treatment methods are limited. Importantly, emerging evidence has investigated that there is a close relationship between endometriosis and autophagy. However, autophagy is a friend or foe in endometriosis is puzzling, the precise mechanism underlying autophagy in endometriosis has not been fully elucidated yet. Here, we provide an integrated view on the acquired findings of the connections between endometriosis and autophagy. We also discuss which may contribute to the abnormal level of autophagy in endometriosis. (C) 2017 Elsevier Inc. All rights reserved.