A New MRI Masking Technique Based on Multi-Atlas Brain Segmentation in Controls and Schizophrenia: A Rapid and Viable Alternative to Manual Masking.
A New MRI Masking Technique Based on Multi-Atlas Brain Segmentation in Controls and Schizophrenia: A Rapid and Viable Alternative to Manual Masking.
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DOI：
10.1111/jon.12313
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发表时间：
2016-01
期刊：
影响因子：
--
通讯作者：
Bouix S
中科院分区：
文献类型：
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作者：
Del Re EC;Gao Y;Eckbo R;Petryshen TL;Blokland GA;Seidman LJ;Konishi J;Goldstein JM;McCarley RW;Shenton ME;Bouix S
MRI图像的脑掩蔽将脑与周围组织分离，其准确性对于进一步的成像分析是重要的。我们实施了一种基于多图谱脑分割（MABS）的新脑掩蔽技术，并将MABS与使用FreeSurfer（FS;版本5.3）、脑提取工具（BET）和Brainwash生成的掩蔽进行比较，使用手动定义的掩蔽（MM）作为金标准。我们进一步确定了不同掩蔽技术对FreeSurfer生成的皮质和皮质下体积的影响。在3特斯拉MR Echospeed系统通用电气扫描仪上采集5名对照组和5名年龄、性别和智商匹配的精神分裂症受试者的图像。从MABS、FS、BET和Brainwash生成自动化掩模，并使用以下指标与MM进行比较：a）与MM的体积差异; B）Dice系数;和c）组内相关系数。MM和MABS面罩之间的平均体积差异显著小于MM和FS或BET面罩之间的差异。MM与MABS之间的Dice系数显著高于MM与FS、BET或Brainwash之间的Dice系数。对于皮质下和左侧皮质区域，MABS体积比BET或FS体积更接近MM体积。对于右侧皮质区域，MABS体积比BET体积更接近MM体积。使用FreeSurfer、BET和Brainwash生成的大脑掩码可以快速获得，但不如手动定义的掩码准确。相比之下，使用MABS生成的掩码更接近手动掩蔽的黄金标准，从而提供了一种快速可行的替代方案。
Brain masking of MRI images separates brain from surrounding tissue and its accuracy is important for further imaging analyses. We implemented a new brain masking technique based on multi-atlas brain segmentation (MABS) and compared MABS to masks generated using FreeSurfer (FS; version 5.3), Brain Extraction Tool (BET), and Brainwash, using manually defined masks (MM) as the gold standard. We further determined the effect of different masking techniques on cortical and subcortical volumes generated by FreeSurfer. Images were acquired on a 3-Tesla MR Echospeed system General Electric scanner on five control and five schizophrenia subjects matched on age, sex, and IQ. Automated masks were generated from MABS, FS, BET, and Brainwash, and compared to MM using these metrics: a) volume difference from MM; b) Dice coefficients; and c) intraclass correlation coefficients. Mean volume difference between MM and MABS masks was significantly less than the difference between MM and FS or BET masks. Dice coefficient between MM and MABS was significantly higher than Dice coefficients between MM and FS, BET, or Brainwash. For subcortical and left cortical regions, MABS volumes were closer to MM volumes than were BET or FS volumes. For right cortical regions, MABS volumes were closer to MM volumes than were BET volumes. Brain masks generated using FreeSurfer, BET, and Brainwash are rapidly obtained, but are less accurate than manually defined masks. Masks generated using MABS, in contrast, resemble more closely the gold standard of manual masking, thereby offering a rapid and viable alternative.