PULSED CO2-LASER TISSUE ABLATION - EFFECT OF TISSUE-TYPE AND PULSE DURATION ON THERMAL-DAMAGE
PULSED CO2-LASER TISSUE ABLATION - EFFECT OF TISSUE-TYPE AND PULSE DURATION ON THERMAL-DAMAGE
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DOI：
10.1002/lsm.1900080204
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发表时间：
1988-01-01
影响因子：
2.4
通讯作者：
DEUTSCH, TF
中科院分区：
文献类型：
--
作者：
WALSH, JT;FLOTTE, TJ;DEUTSCH, TF
红外激光对组织的消融伴随着对非消融组织的热损伤。热损伤的程度可以通过选择激光波长、辐照度和暴露持续时间来控制。已经通过使用脉冲宽度从2 μ sec到50 msec变化的CO2激光器在体内研究了暴露持续时间的影响。50毫秒的脉冲宽度（典型的快门式连续波CO2激光器）在正常豚鼠皮肤中产生750 μ m宽的损伤区域;使用2 μ sec长的脉冲将该损伤区域减小到小至50 μ m。使用2 μ sec长的脉冲，体外研究表明热损伤的最小区域随组织类型而显著变化。这些组织的热变性已被研究并与损伤相关。用一个简单的模型解释了变性温度和脉冲宽度对损伤区宽度的影响。
Tissue remaoval by infrared lasers is accompanied by thermal damage to nonablated tissue. The extent of thermal damage can be controlled by a choice of laser wavelength, irradiance, and exposure duration. The effect of exposure duration has been studied in vivo by using CO2 lasers with pulse widths that vary from 2 .mu.sec to 50 msec. Pulse widths of 50 msec, typical of a shuttered, continuous-wave CO2 laser, produce damage regions 750 .mu.m wide in normal guinea pig skin; the use of a 2-.mu.sec-long pulse reduced this damage zone to as little as 50 .mu.m. Using 2-.mu.sec-long pulses, in vitro studies showed that the minimum zone of thermal damage varied significantly with tissue type. The thermal denaturation of these tissues has been studied and correlated with damage. The effect of denaturation temperature and pulse duration on the width of the damage zone is explained by a simple model.