Evolution of short sequence repeats in Mycobacterium tuberculosis
Evolution of short sequence repeats in Mycobacterium tuberculosis
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DOI：
10.1111/j.1574-6968.2006.00142.x
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发表时间：
2006-03-01
影响因子：
2.1
通讯作者：
Gharbia, S
中科院分区：
文献类型：
--
作者：
Arnold, C;Thorne, N;Gharbia, S
全基因组比较揭示了用于基因分型方案的短序列重复（也称为分枝杆菌散布重复单位和可变数目串联重复单位）的存在。在这项研究中，我们已经使用了删除分析，单核苷酸多态性数据和spoligotype从其他人发表的数据，以调查的演变选定的重复，形成了大多数既定的计划的共同replicators。对来自400多个分离株的每个基因座的重复序列数的分析显示，与祖先菌株相比，全球的总趋势似乎是现代菌株中的重复序列丢失。
Whole genome comparison has revealed the presence of short sequence repeats (also called mycobacterial interspersed repeat units and variable number tandem repeat units) used for genotyping schemes. In this study, we have used deletion analysis, single nucleotide polymorphism data and spoligotype taken from published data from others to investigate the evolution of selected repeats that form the common denominators of the majority of established schemes. Analysis of the number of repeats per locus from over 400 isolates revealed that the general trend globally appears to be loss of repeats in modern strains compared with ancestral strains.