Immunoregulatory T cells in mononucleosis and toxoplasmosis.
Immunoregulatory T cells in mononucleosis and toxoplasmosis.
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单核细胞增多症和弓形虫病中的免疫调节 T 细胞。
DOI：
10.1056/nejm198107233050422
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
B. van Camp
中科院分区：
文献类型：
--
作者：
M. de Waele;C. Thielemans;B. van Camp
使用单克隆抗体在急性巨细胞病毒感染和急性弓形虫病患者的外周淋巴细胞的细胞表面表型进行了测定。在这两名患者中发现大量的OKT 3+和OKT 8 + T细胞，与15名对照组相比，OKT 4+细胞的绝对数量在正常范围内。表达Ia抗原的细胞增加。OKT 8 + T淋巴细胞的活化和增殖可能是细胞内因子感染的一般特征，这些细胞的抑制活性可能限制寄生细胞的增殖。
The cell surface phenotypes of the peripheral lymphocytes were determined using monoclonal antibodies in a patient with acute cytomegalovirus infection and in one with acute toxoplasmosis. In both patients high numbers of OKT3+ and OKT8+ T cells were found, compared with levels in 15 controls; absolute numbers of OKT4+ cells were within the normal range. Cells expressing Ia antigen were increased. Activation and proliferation of OKT8+ T lymphocytes could be a general feature in infections with intracellular agents and the suppressive activity of these cells may limit the proliferation of parasitized cells.