BRAIN-GUT RESPONSE TO STRESS AND CHOLINERGIC STIMULATION IN IRRITABLE-BOWEL-SYNDROME - A PRELIMINARY-STUDY
BRAIN-GUT RESPONSE TO STRESS AND CHOLINERGIC STIMULATION IN IRRITABLE-BOWEL-SYNDROME - A PRELIMINARY-STUDY
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DOI：
10.1097/00004836-199309000-00009
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发表时间：
1993-09-01
影响因子：
2.9
通讯作者：
TAGUCHI, F
中科院分区：
文献类型：
--
作者：
FUKUDO, S;NOMURA, T;TAGUCHI, F
为探讨肠易激综合征（IBS）患者脑-肠相互作用对IBS病理生理的影响，我们对IBS患者（n = 10）和健康对照者（n = 11）在精神应激和服用新斯的明的情况下进行了结肠和小肠压力的测量，同时进行了脑电功率谱分析。与对照组相比，应激使IBS患者的结肠动力指数略有增加，α功率百分比降低，β和θ功率百分比增加（p < 0.05）。IBS患者空腹十二指肠运动Ⅱ相较对照组延长（p < 0.01），Ⅰ相较对照组缩短（p < 0.02）。新斯的明（10 μ g/kg）使IBS患者的结肠动力指数（p < 0.01）和EEG功率谱（p < 0.05）与对照组相比有显著差异。结肠动力与应激（r = 0.46，p < 0.05）或新斯的明（r = 0.51，p < 0.01）引起的功率谱变化呈显著正相关。这些结果表明，IBS患者的肠道和大脑对精神压力和胆碱能刺激的反应性过高。此外，这些夸张的反应可能是相关的。
To investigate the influence of the brain-gut interactions on the pathophysiology of irritable bowel syndrome (IBS), we compared such patients (n = 10) with healthy control subjects (n = 11) by measuring the pressure of the colon and small intestine simultaneously with analysis of power spectrum of the electroencephalography (EEG) under mental stress and administration of neostigmine. Stress slightly increased the colonic motility index, reduced the percentage of alpha power, and increased the percentage of beta and theta power of the EEG in the patients with IBS more than in the controls (p < 0.05). The patients with IBS had a longer phase II (p < 0.01) and shorter phase I (p < 0.02) of fasting duodenal motor activity than the controls. Neostigmine (10 mug/kg) caused a significant difference in the colonic motility index (p < 0.01) and power spectra of EEG (p < 0.05) in the patients with IBS compared to the controls. Significant positive correlation was detected between colonic motility and power spectral change induced by stress (r = 0.46, p < 0.05) or neostigmine (r = 0.51, p < 0.01). These results suggest that patients with IBS have exaggerated responsivity of the gut and the brain to mental stress and cholinergic stimulation. Moreover, there is a possibility that these exaggerated responses are related.