Characteristics of thymus-homing bone marrow cells.
Characteristics of thymus-homing bone marrow cells.
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胸腺归巢骨髓细胞的特征。
DOI：
10.4049/jimmunol.131.1.64
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发表时间：
1983
影响因子：
4.4
通讯作者：
I. Weissman
中科院分区：
文献类型：
--
作者：
F. Lepault;R. Coffman;I. Weissman
使用短期的体内试验，我们研究了骨髓细胞能够归巢到胸腺的致命辐射收件人。在骨髓中，这些细胞缺乏T细胞标志物Thy-1和Lyt。然而，在它们归巢到胸腺后不久，移民开始表达Thy-1和Lyt抗原，但不表达TL抗原。出乎意料的是，Lyt抗原似乎在Thy-1之前表达。这些胸腺归巢的骨髓细胞似乎已经从B细胞谱系中分离出来。大多数归巢细胞参与细胞周期。
Using a short-term in vivo assay, we studied bone marrow cells capable of homing to the thymus of lethally irradiated recipients. In the bone marrow, these cells lack the T cell markers Thy-1 and Lyt. Soon after their homing into the thymus, however, the immigrants begin to express Thy-1 and Lyt antigens, but not TL antigen. Unexpectedly, Lyt antigens appear to be expressed before Thy-1. These thymus-homing bone marrow cells seem to be already separated from the B cell lineage. Most of the homing cells are engaged in the cell cycle.