Studies of herpes simplex virus in newborn mice.
Studies of herpes simplex virus in newborn mice.
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新生小鼠单纯疱疹病毒的研究。
DOI：
10.4049/jimmunol.67.4.321
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发表时间：
1951
影响因子：
4.4
通讯作者：
F. Horsfall
中科院分区：
文献类型：
--
作者：
E. D. Kilbourne;F. Horsfall
新生的(1日龄)瑞士小鼠感染单纯疱疹病毒会引起迅速发展的疾病，最终在3-5天内死亡。这种致命的疾病为病毒和抗体的滴定提供了一个明确的终点。在病毒含量恒定的情况下，中和试验中的血清稀释终点很容易重现。新生小鼠至少与兔或鸡胚胎一样有效地从人的来源恢复疱疹病毒，并具有在首次传代时指示病毒存在的优点。小鼠对通过腹膜内或脑内途径接种单纯疱疹病毒的敏感性随着年龄的增长而降低。3株单纯疱疹病毒的抗原性分析没有发现抗原性差异的证据。
Infection of the newborn (1 day old) Swiss mouse with the virus of herpes simplex results in rapidly progressive disease culminating in death within 3–5 days. This lethal disease provides an unequivocal end point for titrations of virus and antibody. With a constant amount of virus the serum dilution end point in neutralization tests is readily reproducible. The newborn mouse is at least as effective as the rabbit or the chick embryo for the recovery of herpes virus from human sources, and possesses the advantage of indicating the presence of virus on initial passage. Susceptibility of the mouse to inoculation of herpes simplex virus by either the intraperitoneal or intracerebral route decreases with age. Antigenic analysis of 3 herpes simplex virus strains failed to show evidence of antigenic difference.