Evidence-based efficacy of Kampo formulas in a model of non alcoholic fatty liver
Evidence-based efficacy of Kampo formulas in a model of non alcoholic fatty liver
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DOI：
10.3181/0707-rm-207
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发表时间：
2008-03-01
影响因子：
3.2
通讯作者：
Shimada, Yutaka
中科院分区：
文献类型：
--
作者：
Fujimoto, Makoto;Tsuneyama, Koichi;Shimada, Yutaka
有关草药化合物功效的数据往往因缺乏适当的控制或有限的统计能力而受到影响。预防非酒精性脂肪肝病（NAFLD）进展为脂肪性肝炎（NASH）的治疗方法仍然不能令人满意。总共 56 只兔子被分为 7 组，分别喂食标准兔粮 (SRC)、含 1% 胆固醇的 SRC 或五种实验处理中的每一种（汉方配方 1% keishibukuryogan [KBG]、1% orengedokuto [OGT] 和 1% shosaikoto [SST]；维生素 E [VE]；或吡格列酮 [PG]) 于 1% 胆固醇 SRC 中。我们分析了 12 周后血浆和肝脏脂质谱、葡萄糖代谢、脂肪细胞因子、氧化应激和肝纤维化的变化。数据表明，与不补充补充剂相比，所有五种治疗方法均能显着改善血脂、氧化应激和肝纤维化。 KBG在降低肝脏总胆固醇（P < 0.01）和脂质过氧化物酶水平（P < 0.05）、尿8-羟基-2'-脱氧鸟苷（P < 0.05）、肝α-平滑肌肌动蛋白阳性面积（P < 0.01）和活化星状细胞（P < 0.01）方面优于VE和PG。总之，汉方配方（尤其是 KBG）对 NAFLD/NASH 饮食模型具有统计学上显着的益处。未来的研究需要针对 NASH 的治疗机制。
Data on the efficacy of herbal compounds are often burdened by the lack of appropriate controls or a limited statistical power. Treatments to prevent the progression of non alcoholic fatty liver disease (NAFLD) to steatohepatitis (NASH) remain unsatisfactory. A total of 56 rabbits were arrayed into 7 groups fed with standard rabbit chow (SRC), SRC with 1% cholesterol, or each of the five experimental treatments (Kampo formulas 1% keishibukuryogan [KBG], 1% orengedokuto [OGT], and 1% shosaikoto [SST]; vitamin E [VE]; or pioglitazone [PG]) in a 1% cholesterol SRC. We analyzed changes after 12 weeks in plasma and liver lipid profiles, glucose metabolism, adipocytokines, oxidative stress, and liver fibrosis. Data demonstrated that all five treatments were associated with significant amelioration of lipid profiles, oxidative stress, and liver fibrosis compared to no supplementation. KBG was superior to VE and PG in the reduction of liver total cholesterol (P < 0.01) and lipid peroxidase levels (P < 0.05), urinary 8-hydroxy-2'-deoxyguanosine (P < 0.05), hepatic a-smooth muscle actin positive areas (P < 0.01) and activated stellate cells (P < 0.01). In conclusion, there was a statistically significant benefit of Kampo formulas (KBG in particular) on a dietary model of NAFLD/NASH. Future studies need to be directed at the mechanisms in the treatment of NASH.