Consortium neuroscience of attention deficit/hyperactivity disorder and autism spectrum disorder: The ENIGMA adventure.
Consortium neuroscience of attention deficit/hyperactivity disorder and autism spectrum disorder: The ENIGMA adventure.
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注意缺陷/多动障碍与自闭症谱系障碍的神经科学联盟：“脑网络组学国际大科学计划”（ENIGMA）的探索历程 。 注：ENIGMA全称为Enhancing NeuroImaging Genetics through Meta - Analysis，常见中文译名为“脑网络组学国际大科学计划” ，这里结合语境采用此译名。
DOI：
10.1002/hbm.25029
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发表时间：
2022-01
影响因子：
4.8
通讯作者：
Franke B
中科院分区：
文献类型：
--
作者：
Hoogman M;van Rooij D;Klein M;Boedhoe P;Ilioska I;Li T;Patel Y;Postema MC;Zhang-James Y;Anagnostou E;Arango C;Auzias G;Banaschewski T;Bau CHD;Behrmann M;Bellgrove MA;Brandeis D;Brem S;Busatto GF;Calderoni S;Calvo R;Castellanos FX;Coghill D;Conzelmann A;Daly E;Deruelle C;Dinstein I;Durston S;Ecker C;Ehrlich S;Epstein JN;Fair DA;Fitzgerald J;Freitag CM;Frodl T;Gallagher L;Grevet EH;Haavik J;Hoekstra PJ;Janssen J;Karkashadze G;King JA;Konrad K;Kuntsi J;Lazaro L;Lerch JP;Lesch KP;Louza MR;Luna B;Mattos P;McGrath J;Muratori F;Murphy C;Nigg JT;Oberwelland-Weiss E;O'Gorman Tuura RL;O'Hearn K;Oosterlaan J;Parellada M;Pauli P;Plessen KJ;Ramos-Quiroga JA;Reif A;Reneman L;Retico A;Rosa PGP;Rubia K;Shaw P;Silk TJ;Tamm L;Vilarroya O;Walitza S;Jahanshad N;Faraone SV;Francks C;van den Heuvel OA;Paus T;Thompson PM;Buitelaar JK;Franke B
在过去的几十年里，神经影像学已被广泛用于研究注意力缺陷/多动障碍（ADHD）和自闭症谱系障碍（ASD）患者的大脑结构和功能。这些疾病的神经影像学文献的两个主要缺点是所用样本量小和所用方法的异质性。 2013 年和 2014 年，ENIGMA-ADHD 和 ENIGMA-ASD 工作组分别成立，其共同目标是解决这些局限性。在这里，我们对这些工作组迄今为止已完成和仍在进行的项目进行叙述性回顾。由于隐含的分层精神病学诊断分类系统，ADHD 和 ASD 领域在很大程度上是孤立发展的，尽管这些疾病的发生有相当大的重叠。 ENIGMA-ADHD 和 ‐ASD 工作组之间的合作旨在使这两种疾病的神经影像学工作更加紧密地结合在一起。皮层下和皮层结构的病例对照研究结果表明，皮层下体积在 ASD 和 ADHD 中受到类似的影响，尽管影响较小。皮质分析发现了每种疾病的独特差异，但两者之间也有相当大的重叠，特别是在皮质厚度方面。正在进行的工作正在研究替代研究问题，例如大脑偏侧性、病例对照状态的预测和解剖异质性。简而言之，在实现 ENIGMA 合作的目标方面已经取得了长足的进步，同时新的想法和后续分析仍在继续，包括更多的成像模式（扩散 MRI 和静息态功能 MRI）、与其他大型数据库的合作以及具有双重诊断的样本。
Neuroimaging has been extensively used to study brain structure and function in individuals with attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) over the past decades. Two of the main shortcomings of the neuroimaging literature of these disorders are the small sample sizes employed and the heterogeneity of methods used. In 2013 and 2014, the ENIGMA‐ADHD and ENIGMA‐ASD working groups were respectively, founded with a common goal to address these limitations. Here, we provide a narrative review of the thus far completed and still ongoing projects of these working groups. Due to an implicitly hierarchical psychiatric diagnostic classification system, the fields of ADHD and ASD have developed largely in isolation, despite the considerable overlap in the occurrence of the disorders. The collaboration between the ENIGMA‐ADHD and ‐ASD working groups seeks to bring the neuroimaging efforts of the two disorders closer together. The outcomes of case–control studies of subcortical and cortical structures showed that subcortical volumes are similarly affected in ASD and ADHD, albeit with small effect sizes. Cortical analyses identified unique differences in each disorder, but also considerable overlap between the two, specifically in cortical thickness. Ongoing work is examining alternative research questions, such as brain laterality, prediction of case–control status, and anatomical heterogeneity. In brief, great strides have been made toward fulfilling the aims of the ENIGMA collaborations, while new ideas and follow‐up analyses continue that include more imaging modalities (diffusion MRI and resting‐state functional MRI), collaborations with other large databases, and samples with dual diagnoses.
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