Potassium Exchange in the Dog Heart in Situ
Potassium Exchange in the Dog Heart in Situ
复制标题
狗心脏的钾离子交换
DOI：
10.1161/01.res.13.4.279
复制
发表时间：
1963
影响因子：
20.1
通讯作者：
G. Grupp
中科院分区：
文献类型：
--
作者：
G. Grupp
恒定流量和恒定比活度的冠状动脉灌注允许对狗心脏原位两个方向的钾跨膜通量进行估计。流出量的测定基于冲洗特征。研究范围内的灌注压和冠状动脉流量对流出量影响很小。流入量的估计涉及使用同一实验的流出量对实验数据进行校正，因此不太准确；由于灌注区域侧支血液供应的变化，它会发生变化。心脏与心脏之间的流出量差异为 50%，平均心率为 130 次/分钟时，平均为 0.68 mEq K+/kg/min。心率变化表明，每次心跳交换的 K+/kg 高于不跳动心脏的静息通量；后者经外推估计为 0.55 mEq K+/kg 和 min。
Coronary perfusion with constant flow and constant specific activity permitted an estimate of the transmembrane fluxes of potassium in both directions in the dog heart in situ. The determination of efflux was based on the washout characteristics. Perfusion pressure and coronary flow within the limits studied have little influence on efflux. The estimate of influx involved correction of experimental data using the efflux from the same experiment and is therefore less accurate; it is subject to changes due to alterations in collateral blood supply of the perfusion area. The efflux varies by 50% from heart to heart, averaging 0.68 mEq K+/kg and min at an average heart rate of 130 beats/min. Changes in heart rate reveal that 1.65 μEq K+/kg are exchanged per beat above the resting flux of the nonbeating heart; the latter was estimated by extrapolation to be 0.55 mEq K+/kg and min.