Effects of overfeeding on the neuronal response to visual food cues
Effects of overfeeding on the neuronal response to visual food cues
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DOI：
10.1093/ajcn/86.4.965
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发表时间：
2007-10-01
影响因子：
7.1
通讯作者：
Tregellas, Jason R.
中科院分区：
文献类型：
--
作者：
Cornier, Marc-Andre;Von Kaenel, Sandra S.;Tregellas, Jason R.
背景资料：能量摄入的调节是一个复杂的过程，涉及稳态信号和内部和外部感觉输入的整合。环境视觉线索是第一和主要的输入信号的潜在availability of food.Objective：我们研究的影响短期过度喂养的神经元反应的食物相关的视觉stimulations.Design：25薄的个人（13名女性，12名男性）进行了研究。功能性磁共振成像（fMRI）进行后，2天的热量摄入和2天后的30%过量喂养的平衡设计。当受试者呈现3种不同类别的视觉刺激时进行fMRI：中性控制对象，中性享乐价值的食物和高享乐价值的食物。食欲的措施，通过使用视觉模拟量表之前和之后meaning.Results：在eucaloric状态，图片的高享乐价值的食物引起更大的激活神经元区域比中性评级的食物，这是一致的视觉处理和注意（下颞叶视觉皮层，后顶叶皮层，运动前皮层，海马）和下丘脑的激活。两天的过度喂食导致这些反应显着减弱。过度喂养也导致减少饥饿评级和增加饱rates.Conclusion：这些研究结果强调了外部食物相关的视觉线索的重要作用，并建议有外部视觉感官输入，能量平衡状态，和大脑区域之间的相互作用重要的能量摄入的稳态调节。
Background: The regulation of energy intake is a complex process involving the integration of homeostatic signals and both internal and external sensory inputs. Environmental visual cues are one of the first and primary inputs signaling the potential availability of food.Objective: We examined the effects of short-term overfeeding on the neuronal responses to food-related visual stimuli in thin individuals.Design: Twenty-five thin individuals (13 women, 12 men) were studied. Functional magnetic resonance imaging (fMRI) was performed after 2 days of eucaloric energy intake and after 2 days of 30% overfeeding in a counterbalanced design. fMRI was performed while the subjects were presented with visual stimuli in 3 different categories: neutral control objects, foods of neutral hedonic value, and foods of high hedonic value. Measures of appetite were obtained by using visual analogue scales before and after meals.Results: In the eucaloric state, pictures of foods of high hedonic value elicited greater activation of neuronal regions than did neutrally rated foods, which is consistent with visual processing and attention (inferior temporal visual cortex, posterior parietal cortex, premotor cortex, and hippocampus) and with activation of the hypothalamus. Two days of overfeeding led to significant attenuation of these responses. Overfeeding also resulted in reduced hunger ratings and increased satiety ratings.Conclusion: These findings emphasize the important role of external food-related visual cues and suggest that there are interactions between external visual sensory inputs, energy balance status, and brain regions important in the homeostatic regulation of energy intake.