Harnessing the power of the endosome to regulate neural development.
Harnessing the power of the endosome to regulate neural development.
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DOI:
10.1016/j.neuron.2012.04.015
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发表时间:
2012-05-10
期刊:
影响因子:
16.2
通讯作者:
Winckler B
中科院分区:
文献类型:
--
作者:
Yap CC;Winckler B
Endocytosis and endosomal trafficking play a multitude of roles in cellular function beyond regulating entry of essential nutrients. In this review, we discuss the cell biological principles of endosomal trafficking, the neuronal adaptations to endosomal organization, and the role of endosomal trafficking in neural development. In particular, we consider how cell fate decisions, polarity, migration, and axon outgrowth and guidance are influenced by five endosomal tricks: dynamic modulation of receptor levels by endocytosis and recycling, cargo-specific responses via cargo-specific endocytic regulators, cell type-specific endocytic regulation, ligand-specific endocytic regulation, and endosomal regulation of ligand processing and trafficking.
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DOI:
10.1523/jneurosci.1542-09.2009
发表时间:
2009-09-16
期刊:
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子:
--
作者:
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通讯作者:
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DOI:
10.1083/jcb.200408165
发表时间:
2004-11-08
期刊:
The Journal of cell biology
影响因子:
--
作者:
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通讯作者:
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影响因子:
3.5
作者:
Chao, Wei-Ting;Kunz, Jeannette
通讯作者:
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影响因子:
4.8
作者:
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影响因子:
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作者:
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