Biomarker discovery in human SLE nephritis.
Biomarker discovery in human SLE nephritis.
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发表时间：
2007
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通讯作者：
B. Rovin;D. Birmingham;H. Nagaraja;C. Y. Yu;L. Hebert
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作者：
B. Rovin;D. Birmingham;H. Nagaraja;C. Y. Yu;L. Hebert
系统性红斑狼疮（SLE）肾炎的治疗虽然有效，但与显著的发病率和死亡率相关。如果可以预测肾性发作的发作、严重程度和反应，并相应地调整治疗，则可以减轻这些副作用。本文综述了SLE肾炎发作预测方程的推导方法。生成这样的预测方程不可或缺的是识别狼疮肾炎的生物标志物，其可以作为用于对耀斑建模的输入变量。使用尿液作为SLE肾炎生物标志物的来源进行了描述，并提出了使用候选和蛋白质组学方法的尿液生物标志物发现研究的结果。
The treatment of systemic lupus erythematosus (SLE) nephritis, while effective, is associated with significant morbidity and mortality. These side effects could be mitigated if the onset, severity, and response of renal flare could be predicted, and therapy modified accordingly. In this review, an approach to derive prediction equations of SLE nephritis flare is discussed. Integral to generating such prediction equations is the identification of biomarkers of lupus nephritis that can serve as input variables for modeling flare. The use of urine as a source of SLE nephritis biomarkers is described, and the results of urine biomarker discovery studies using candidate and proteomic approaches are presented.