Autophagy signal transduction by ATG proteins: from hierarchies to networks.
Autophagy signal transduction by ATG proteins: from hierarchies to networks.
复制标题
ATG 蛋白的自噬信号转导：从层次结构到网络。
DOI：
10.1007/s00018-015-2034-8
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发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
Stork B
中科院分区：
文献类型：
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作者：
Wesselborg S;Stork B
自噬是一种细胞内降解过程，参与细胞内稳态和疾病环境。在过去的二十年中，控制这一过程的分子机制已被详细描述。到目前为止，已经确定了几个调节这种细胞内降解过程的关键因素。所谓的自噬相关（ATG）基因和蛋白质是这一过程的核心。然而，一些额外的分子有助于自噬反应的结果。最近发表了几篇描述自噬分子过程的综述文章。在这篇综述文章中，我们想增加最新的发现，这方面的知识，并给出了自噬信号机制的网络字符的概述。本文的在线版本（doi：10.1007/s 00018 -015-2034-8）包含补充材料，可供授权用户使用。
Autophagy represents an intracellular degradation process which is involved in both cellular homeostasis and disease settings. In the last two decades, the molecular machinery governing this process has been characterized in detail. To date, several key factors regulating this intracellular degradation process have been identified. The so-called autophagy-related (ATG) genes and proteins are central to this process. However, several additional molecules contribute to the outcome of an autophagic response. Several review articles describing the molecular process of autophagy have been published in the recent past. In this review article we would like to add the most recent findings to this knowledge, and to give an overview of the network character of the autophagy signaling machinery. The online version of this article (doi:10.1007/s00018-015-2034-8) contains supplementary material, which is available to authorized users.