Fucosylated Antigens in Cancer: An Alliance toward Tumor Progression, Metastasis, and Resistance to Chemotherapy.
Fucosylated Antigens in Cancer: An Alliance toward Tumor Progression, Metastasis, and Resistance to Chemotherapy.
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DOI：
10.3389/fonc.2018.00039
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发表时间：
2018
影响因子：
4.7
通讯作者：
van Vliet SJ
中科院分区：
文献类型：
--
作者：
Blanas A;Sahasrabudhe NM;Rodríguez E;van Kooyk Y;van Vliet SJ
Aberrant glycosylation of tumor cells is recognized as a universal hallmark of cancer pathogenesis. Overexpression of fucosylated epitopes, such as type I (H1, Lewisa, Lewisb, and sialyl Lewisa) and type II (H2, Lewisx, Lewisy, and sialyl Lewisx) Lewis antigens, frequently occurs on the cancer cell surface and is mainly attributed to upregulated expression of pertinent fucosyltransferases (FUTs). Nevertheless, the impact of fucose-containing moieties on tumor cell biology is not fully elucidated yet. Here, we review the relevance of tumor-overexpressed FUTs and their respective synthesized Lewis determinants in critical aspects associated with cancer progression, such as increased cell survival and proliferation, tissue invasion and metastasis, epithelial to mesenchymal transition, epithelial and immune cell interaction, angiogenesis, multidrug resistance, and cancer stemness. Furthermore, we discuss the potential use of enhanced levels of fucosylation as glycan biomarkers for early prognosis, diagnosis, and disease monitoring in cancer patients.
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影响因子：
6.4
作者：
Duffy, M. J.;Lamerz, R.;Haglund, C.;Nicolini, A.;Kalousova, M.;Holubec, L.;Sturgeon, C.
通讯作者：
Sturgeon, C.
影响因子：
6
作者：
Brazil, Jennifer C.;Sumagin, Ronen;Parkos, Charles A.
通讯作者：
Parkos, Charles A.
影响因子：
3.9
作者：
Abrantes, Joana;Posada, David;Le Pendu, Jacques
通讯作者：
Le Pendu, Jacques
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作者：
Desiderio V;Papagerakis P;Tirino V;Zheng L;Matossian M;Prince ME;Paino F;Mele L;Papaccio F;Montella R;Papaccio G;Papagerakis S
通讯作者：
Papagerakis S
影响因子：
5.5
作者：
de Jong, Marein A. W. P.;de Witte, Lot;Geijtenbeek, Teunis B. H.
通讯作者：
Geijtenbeek, Teunis B. H.