Neuronal and behavioral correlations in the medial prefrontal cortex and nucleus accumbens during cocaine self-administration by rats
Neuronal and behavioral correlations in the medial prefrontal cortex and nucleus accumbens during cocaine self-administration by rats
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DOI：
10.1016/s0306-4522(00)00218-9
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发表时间：
2000-01-01
期刊：
影响因子：
3.3
通讯作者：
Woodward, DJ
中科院分区：
文献类型：
--
作者：
Chang, JY;Janak, PH;Woodward, DJ
多达31个神经元，每只动物同时记录从内侧前额叶皮层和神经核在15只大鼠在静脉注射可卡因自我管理会议，使用多通道，单单位记录技术。神经元活动（兴奋性和抑制性）的变化被发现前几秒钟，每一个杠杆按可卡因输液，我们称这些前杠杆按神经元激活“预期反应”。一项偏离轨道的视频分析显示，这些神经元放电的改变与两个记录区域中每次按下杠杆之前执行的行为序列的特定部分有关。一些同时记录的神经元显示出与行为序列中给定的行为事件（转动，抬起头等）相关的类似放电模式，交叉相关分析揭示了同时记录的内侧前额叶皮层和中脑核神经元之间的区域间和区域内相关放电模式。这种相关放电发生在有和无预期反应的神经元中，尽管预期反应神经元对之间的相关发生率远高于非预期反应神经元对之间的相关发生率（18.4%vs3.6%），但许多相关神经元对的相关活动峰值出现时间滞后，表明相关活动的时间顺序。与我们的假设相矛盾的是，相关性的时间模式显示，有更多的情况下，在内侧前额叶皮层神经元前发射nucleus神经元，结果表明，多个mesocorticolimbic神经元回路可能代码的行为序列中执行的步骤，以获得可卡因的输液。所观察到的内侧前额叶皮层和脑桥核之间的相关放电表明，动态的，连贯的活动发生在mesocorticolimbic电路。因为这个电路被假设为驱动药物寻求行为，我们认为，这种相关的发射之间的核延髓和内侧前额叶皮质可能参与可卡因自我管理的控制。此外，研究发现，相关的活动，在核内的脑桥更经常之前的内侧前额叶皮层表明，核脑桥可能发挥了主要作用，在启动可卡因自我管理。(C)2000 IBRO。由爱思唯尔科技有限公司出版。保留所有权利。
Up to 31 neurons per animal were simultaneously recorded from the medial prefrontal cortex and nucleus accumbens in 15 rats during i.v. cocaine self-administration sessions, using a multi-channel, single-unit recording technique. Alterations of neuronal activity (both excitatory and inhibitory) were found a few seconds before each lever press for cocaine infusion; we have called these pre-lever press neuronal activations "anticipatory responses". A derailed video analysis revealed that these neuronal firing alterations were associated with specific portions of the behavioral sequence performed before each lever press in both recording areas. Some of the simultaneously recorded neurons displayed similar firing patterns in relation to a given behavioral episode within the behavioral sequence (turning, raising head, etc.), while others fired at different times relative to each behavioral event, Cross-correlational analyses revealed inter-regional and intra-regional correlated firing patterns between pairs of simultaneously recorded medial prefrontal cortex and nucleus accumbens neurons. This correlated firing occurred in the neurons with and without anticipatory responses, although the incidence of correlations between anticipatory neuron pairs was much higher than that between non-anticipatory neuron pairs (18.4% vs 3.6%), Many correlated neuron pairs displayed a time lag in the peak of correlational activity that indicated a temporal sequence in correlated activity. In contradiction to our hypothesis, the temporal pattern of correlation reveals that there are more cases in which nucleus accumbens neurons fired ahead of medial prefrontal cortex neurons.The results suggest that multiple mesocorticolimbic neuronal circuits may code sequential steps during the behavioral sequence performed to obtain an infusion of cocaine. The observed correlated firing between the medial prefrontal cortex and the nucleus accumbens indicates that dynamic, coherent activity occurs within the mesocorticolimbic circuit. Because this circuit is hypothesized to drive drug-seeking behavior, we suggest that this correlated firing between the nucleus accumbens and the medial prefrontal cortex may participate in the control of cocaine self-administration. In addition, the finding that correlated activity within the nucleus accumbens more often precedes that of the medial prefrontal cortex suggests that the nucleus accumbens may play a prime role in the initiation of cocaine self-administration. (C) 2000 IBRO. Published by Elsevier Science Ltd. All rights reserved.