Gene signatures reflect the marked heterogeneity of tissue-resident macrophages
Gene signatures reflect the marked heterogeneity of tissue-resident macrophages
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DOI：
10.1038/sj.icb.7100131
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发表时间：
2008-03-01
影响因子：
4
通讯作者：
Clark, Hilary F.
中科院分区：
文献类型：
--
作者：
Gorgani, Nick N.;Ma, Yan;Clark, Hilary F.
组织内巨噬细胞在防御病原体中发挥重要作用，并在器官稳态、先天免疫和适应性免疫中发挥关键作用。组织巨噬细胞起源于血液单核细胞，几乎渗透到身体的每个器官。不同组织中的巨噬细胞具有许多共同的特征，包括迁移、吞噬颗粒、代谢脂质和呈递抗原的能力。它们在形态上是异质的，并且有一些不同的功能被报道。巨噬细胞的基因表达谱反映了它们共同的和独特的生物学功能。在这里，我们发现来自小鼠脾脏、肝脏和腹膜的巨噬细胞表现出明显不同的表达谱。研究发现，基因簇具有与粘附、抗原呈递、吞噬、脂质代谢和信号转导相关的独特生物学功能。一些基因家族，如整合素，在不同组织中巨噬细胞的表达是不同的，这表明巨噬细胞的驻留组织影响其生物学功能。
Tissue-resident macrophages play an important role in defense against pathogens and perform key functions in organ homeostasis, innate and adaptive immunity. Tissue macrophages originate from blood monocytes that infiltrate virtually every organ in the body. Macrophages in different tissues share many characteristics, including their ability to migrate, phagocytose particles, metabolize lipids and present antigens. Morphologically they are quite heterogeneous, and some distinct functions have been reported. The gene expression profile of macrophages is reflective of both their shared and distinct biological functions. Here, we show that macrophages from murine spleen, liver and peritoneum display dramatically different expression profiles. Clusters of genes were found to represent unique biological functions related to adhesion, antigen presentation, phagocytosis, lipid metabolism and signal transduction. Some gene families, such as integrins, are differentially expressed among the macrophages resident in different tissues, suggesting that the tissue of residence influences their biological function.