Aggregation and combination of cardiovascular risk factors and their association with 10-year all-cause mortality: the PERU MIGRANT Study.
Aggregation and combination of cardiovascular risk factors and their association with 10-year all-cause mortality: the PERU MIGRANT Study.
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DOI：
10.1186/s12872-021-02405-8
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发表时间：
2021-12-07
影响因子：
2.1
通讯作者：
Bernabe-Ortiz A
中科院分区：
文献类型：
--
作者：
Bazalar-Palacios J;Jaime Miranda J;Carrillo-Larco RM;Gilman RH;Smeeth L;Bernabe-Ortiz A
评估选定的心血管危险因素(CVRF)的聚集和成对组合与10年全因死亡率之间的关联。秘鲁移民研究的二次数据分析，这是一项基于人群的前瞻性队列研究。通过国家身份和公民身份登记处，确定了最初参加秘鲁移民研究的参与者的十年全因死亡率(2007年基线)。CVRF包括高血压、2型糖尿病、高胆固醇血症和超重/肥胖。暴露由选定的CVRF(一个、两个和三个或更多个CVRF)的聚集和CVRF的成对组合组成。用COX回归模型计算危险比(HR)和95%可信区间(95%CI)。在基线评估的989名参与者中，976人(98.8%)在10年(9992.63人年)的随访中获得了有关生命状况的信息，并记录了63例死亡。在调整了社会人口学和生活方式变量的多变量模型中，有两个CVRF的参与者(HR：2.48，95%CI：1.03-5.99)和有三个或更多CVRF的参与者(HR：3.93，95%CI：1.21-12.74)比没有任何CVRF的参与者有更高的全因死亡风险。与未合并其他疾病的患者相比，高血压合并2型糖尿病(HR：11.67，95%CI：3.67-37.10)和高血压合并超重/肥胖(HR：2.76，95%CI：1.18-6.71)风险最高。两个或更多CVRF的聚集以及高血压合并2型糖尿病或超重/肥胖与10年全因死亡的风险增加相关。这些风险概况将为一级和二级预防战略提供信息，以推迟心血管危险因素造成的死亡。网上版载有补充材料，可在10.1186/s12872-021-02405-8查阅。
To estimate the association between the aggregation and pair-wise combination of selected cardiovascular risk factors (CVRF) and 10-year all-cause mortality. Secondary data analysis of the PERU MIGRANT study, a prospective population-based cohort. Ten-year all-cause mortality was determined for participants originally enrolled in the PERU MIGRANT Study (baseline in 2007) through the National Registry of Identification and Civil Status. The CVRF included hypertension, type 2 diabetes mellitus, hypercholesterolemia, and overweight/obesity. Exposures were composed of both the aggregation of the selected CVRF (one, two, and three or more CVRF) and pair-wise combinations of CVRF. Cox regression models were used to calculate hazard ratios (HR) and 95% confidence intervals (95% CI). Of the 989 participants evaluated at baseline, 976 (98.8%) had information about vital status at 10 years of follow-up (9992.63 person-years), and 63 deaths were recorded. In the multivariable model, adjusting for sociodemographic and lifestyle variables, participants with two CVRF (HR: 2.48, 95% CI: 1.03–5.99), and those with three or more CVRF (HR: 3.93, 95% CI: 1.21–12.74) had higher all-cause mortality risk, compared to those without any CVRF. The pair-wise combinations associated with the highest risk of all-cause mortality, compared to those without such comorbidities, were hypertension with type 2 diabetes (HR: 11.67, 95% CI: 3.67–37.10), and hypertension with overweight/obesity (HR: 2.76, 95% CI: 1.18–6.71). The aggregation of two or more CVRF and the combination of hypertension with type 2 diabetes or overweight/obesity were associated with an increased risk of 10-year all-cause mortality. These risk profiles will inform primary and secondary prevention strategies to delay mortality from cardiovascular risk factors. The online version contains supplementary material available at 10.1186/s12872-021-02405-8.
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影响因子：
3.7
作者：
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通讯作者：
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