DIAGNOSTIC STRATEGIES FOR SUBCLINICAL HYPOTHYROIDISM
DIAGNOSTIC STRATEGIES FOR SUBCLINICAL HYPOTHYROIDISM
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DOI：
10.1007/s12291-008-0062-y
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发表时间：
2008-07-01
影响因子：
2.1
通讯作者：
Rao, Pragna
中科院分区：
文献类型：
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作者：
Mohanty, Shruti;Amruthlal, W.;Rao, Pragna
本研究的目的是描述亚临床甲状腺功能减退症患者的实验室诊断策略，这些患者有临床症状，但甲状腺功能正常。采用电化学发光法测定99例患者空腹血中的三碘甲状腺原氨酸（T-3）、甲状腺素（T-4）、促甲状腺激素（TSH）和抗甲状腺过氧化物酶抗体（抗TPO）。74%的研究受试者抗TPO水平升高。61%的患者存在亚临床甲减。61例亚临床甲状腺功能减退患者中有45例（73%）抗TPO水平升高。这是一个重要的发现，提示亚临床甲状腺功能障碍的自身免疫病因，具有发展为明显甲状腺功能减退的较高风险。
The aim of this study is to delineate laboratory diagnostic strategies for subclinical hypothyroidism in patients who are clinically symptomatic but may have a normal thyroid profile. Tri-iodothyronine (T-3), thyroxine (T-4), thyroid stimulating hormone (TSH) and anti thyroid peroxidase antibodies (anti-TPO) were estimated on fasting blood samples from 99 patients using electrochemiluminescence methods on ELECSYS 1010 (Roche). 74 % of study subjects had elevated anti-TPO levels. 61 % patients had subclinical hypothyroidism. 45 of the 61 subclinical hypothyroid patients had elevated anti-TPO levels (73%). This is an important finding suggesting an autoimmune etiology for subclinical thyroid dysfunction with a higher risk of developing overt hypothyroidism.