PRENATAL AND POSTNATAL LEAD-EXPOSURE AND BEHAVIOR PROBLEMS IN SCHOOL-AGED CHILDREN
PRENATAL AND POSTNATAL LEAD-EXPOSURE AND BEHAVIOR PROBLEMS IN SCHOOL-AGED CHILDREN
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DOI：
10.1006/enrs.1994.1041
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发表时间：
1994-07-01
影响因子：
8.3
通讯作者：
RABINOWITZ, M
中科院分区：
文献类型：
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作者：
BELLINGER, D;LEVITON, A;RABINOWITZ, M
在一家医院 12 个月内出生的一组 8 岁儿童中，对早期铅暴露与后期问题行为之间的关联进行了前瞻性评估。脐带血中的铅含量（($) 超过条形 X = 6.8 mu g/dl，SD = 3.1）和脱落乳牙的牙本质（($) 超过波浪号 X = 3.4 mu g/g，SD = 2.4）分别提供了产前和产后暴露的测量。儿童行为概况教师报告表上的评级提供了有关儿童问题行为的信息。脐带血铅水平与问题行为的总体患病率或性质无关。在粗略分析和调整分析中，牙铅水平与总问题行为评分显着相关（牙铅每增加对数单位，T 分数大约为 2 分）。还观察到与牙导相关的内化和外化分数显着增加（每增加对数单位，T 分数大约增加 1.5 分）。牙齿铅水平与“极端”问题行为评分的流行率之间的关联性较弱。这些关联在多大程度上反映了残余混杂因素尚不确定。然而，这些数据表明，社交和情绪功能障碍是相关的，并且可能是铅暴露增加的表现。 (C) 1994 年学术出版社
The association between early lead exposure and later problem behaviors was evaluated prospectively in a cohort of 8-year-old children born during a 12-month period at one hospital. Lead levels in umbilical cord blood (($) over bar X = 6.8 mu g/dl, SD = 3.1) and the dentin of a shed deciduous tooth (($) over tilde X = 3.4 mu g/g, SD = 2.4) provided measures of prenatal and postnatal exposure, respectively. Ratings on the Teacher Report Form of the Child Behavior Profile provided information about children's problem behaviors. Cord blood lead level was not associated with the overall prevalence or nature of problem behaviors. In both crude and adjusted analyses, tooth lead level was significantly associated with total problem behavior scores (approximately 2 points in T score per log unit increase in teeth lead). Significant tooth lead-associated increases in both internalizing and externalizing scores were also observed (approximately 1.5 points in T score per log unit increase). Weaker associations were noted between tooth lead level and the prevalence of ''extreme'' problem behavior scores. The extent to which these associations reflect residual confounding is uncertain. These data suggest, however, that social and emotional dysfunctions are correlates and may be expressions of increased lead exposure. (C) 1994 Academic Press, Inc.