Contrast Agent-Free Assessment of Blood Flow and Wall Shear Stress in the Rabbit Aorta using Ultrasound Image Velocimetry.
Contrast Agent-Free Assessment of Blood Flow and Wall Shear Stress in the Rabbit Aorta using Ultrasound Image Velocimetry.
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DOI：
10.1016/j.ultrasmedbio.2021.10.010
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发表时间：
2022-03
影响因子：
2.9
通讯作者：
Weinberg PD
中科院分区：
文献类型：
--
作者：
Riemer K;Rowland EM;Broughton-Venner J;Leow CH;Tang M;Weinberg PD
血流速度和壁面剪切应力（WSS）对血管疾病的影响和影响。因此，它们的测量在实验室和临床都是有用的。对比增强超声图像测速（UIV）可以准确地估计它们，但需要注射造影剂限制了效用。奇异值分解和高帧率成像可能使造影剂变得可有可无。在这里，我们确定了无造影剂的uv是否可以测量流量和WSS。在仿真中，精确测量的信噪比达到13.5 dB或更高。兔主动脉信号强度随力学指数单调增加；在停滞流动和船舶不均匀时，它是最低的。无对比和增强对比的体内测量在速度大小和角度上分别相差4.4%和1.9%，在WSS上相差9.47%。Bland-Altman波形分析显示无对比度和增强对比度的uv具有良好的一致性。5只家兔的均方根误差分别为0.022 m/s（0.81%）和0.11 Pa（1.7%）。该研究表明，通过优化的方案，uv可以在不使用造影剂的情况下评估血流和WSS。与对比度增强的紫外线照射不同，无对比度紫外线照射可以常规使用。
Blood flow velocity and wall shear stress (WSS) influence and are influenced by vascular disease. Their measurement is consequently useful in the laboratory and clinic. Contrast-enhanced ultrasound image velocimetry (UIV) can estimate them accurately but the need to inject contrast agents limits utility. Singular value decomposition and high-frame-rate imaging may render contrast agents dispensable. Here we determined whether contrast agent-free UIV can measure flow and WSS. In simulation, accurate measurements were achieved with a signal-to-noise ratio of 13.5 dB or higher. Signal intensity in the rabbit aorta increased monotonically with mechanical index; it was lowest during stagnant flow and uneven across the vessel. In vivo measurements with contrast-free and contrast-enhanced UIV differed by 4.4% and 1.9% for velocity magnitude and angle and by 9.47% for WSS. Bland–Altman analysis of waveforms revealed good agreement between contrast-free and contrast-enhanced UIV. In five rabbits, the root-mean-square errors were as low as 0.022 m/s (0.81%) and 0.11 Pa (1.7%). This study indicates that with an optimised protocol, UIV can assess flow and WSS without contrast agents. Unlike contrast-enhanced UIV, contrast-free UIV could be routinely employed.
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影响因子：
10.6
作者：
Baranger, Jerome;Arnal, Bastien;Demene, Charlie
通讯作者：
Demene, Charlie
影响因子：
10.6
作者：
Demene, Charlie;Deffieux, Thomas;Tanter, Mickael
通讯作者：
Tanter, Mickael
影响因子：
2.4
作者：
Feng, J.;Khir, A. W.
通讯作者：
Khir, A. W.
影响因子：
2.9
作者：
BRANDS, PJ;HOEKS, APG;RENEMAN, RS
通讯作者：
RENEMAN, RS
DOI：
10.1109/58.139123
发表时间：
1992-03-01
影响因子：
3.6
作者：
JENSEN, JA;SVENDSEN, NB
通讯作者：
SVENDSEN, NB