Models of Low Reynolds Number Swimmers Inspired by Cell Blebbing
Models of Low Reynolds Number Swimmers Inspired by Cell Blebbing
复制标题
受细胞起泡启发的低雷诺数游泳者模型
DOI：
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
H. Othmer
中科院分区：
文献类型：
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作者：
Qixuan Wang;Jifeng Hu;H. Othmer
真核细胞通过附着在细胞外基质上（有时会局部降解）并沿着拉动自己，或者通过适当的形状变化顺序挤压基质，从而在组织的复杂微环境中移动。一些细胞甚至可以通过形状变化来游动，其中一种模式被称为起泡，其中一个细胞产生一个小的半球形突起，该突起可以生长以合并整个细胞体积，或者可以被重新吸收到初级体积中。在这里，我们开发和分析几个模型，在低雷诺数游泳细胞起泡的启发。这些模型包括几个连接的球体，并且每个连接的球体对可以与其对中的互补体交换体积。我们表明，细胞可以推动自己通过流体使用合适的顺序的体积交换，我们评估这种模式的游泳的效率。
Eukaryotic cells move through the complex micro-environment of a tissue either by attaching to the extracellular matrix – sometimes degrading it locally – and pulling themselves along, or by squeezing through the matrix by appropriate sequences of shape changes. Some cells can even swim by shape changes, and one mode used is called blebbing, in which a cell creates a small hemispherical protrusion that may grow to incorporate the entire cell volume or may be reabsorbed into the primary volume. Herein we develop and analyze several models for swimming at low Reynolds number inspired by cell blebbing. These models comprise several connected spheres, and each connected pair of spheres can exchange volume with their complement in the pair. We show that the cell can propel itself through the fluid using a suitable sequence of volume exchanges, and we evaluate the efficiency of this mode of swimming.