Involvement of spindles in memory consolidation is slow wave sleep-specific
Involvement of spindles in memory consolidation is slow wave sleep-specific
复制标题
DOI：
10.1101/lm.026252.112
复制
发表时间：
2012-07-01
影响因子：
2
通讯作者：
Talamini, Lucia M.
中科院分区：
文献类型：
--
作者：
Cox, Roy;Hofman, Winni F.;Talamini, Lucia M.
睡眠纺锤波和慢振荡都与睡眠依赖的记忆巩固有关。尽管纺锤波在浅睡眠和深睡眠中都出现，但慢振荡仅限于深睡眠，这增加了深睡眠期间与巩固相关的纺锤波参与的可能性。我们评估了在包含小睡的时间间隔内的陈述性记忆保留，并分别确定了浅睡眠和深睡眠的纺锤体密度。在深度睡眠中，纺锤体密度相当高，并显示出与保持力的强有力的正相关。这种关系在轻度睡眠中是不存在的，这表明纺锤波的增强作用与它们与缓慢振荡的共同出现有关。
Both sleep spindles and slow oscillations have been implicated in sleep-dependent memory consolidation. Whereas spindles occur during both light and deep sleep, slow oscillations are restricted to deep sleep, raising the possibility of greater consolidation-related spindle involvement during deep sleep. We assessed declarative memory retention over an interval containing a nap and determined spindle density for light and deep sleep separately. In deep sleep, spindle density was considerably higher and showed a strong and robust positive correlation with retention. This relation was absent for light sleep, suggesting that the potentiating effects of spindles are tied to their co-occurrence with slow oscillations.