Depressive symptoms and metabolic syndrome: is inflammation the underlying link?
Depressive symptoms and metabolic syndrome: is inflammation the underlying link?
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DOI：
10.1016/j.biopsych.2008.05.019
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发表时间：
2008-11-15
影响因子：
10.6
通讯作者：
Vaccarino, Viola
中科院分区：
文献类型：
--
作者：
Capuron, Lucile;Su, Shaoyong;Miller, Andrew H.;Bremner, J. Douglas;Goldberg, Jack;Vogt, Gerald J.;Maisano, Carisa;Jones, Linda;Murrah, Nancy V.;Vaccarino, Viola
在代谢综合征（MetS）的个体中，包括抑郁在内的行为改变，包括抑郁症。最近的发现表明，可能涉及长期激活先天免疫力。这项研究的目的是检查Mets与抑郁症状之间的关系，并阐明炎症在这种关系中的参与。
参与者是323个男双胞胎，有和没有Met，并且没有症状性心血管疾病，由越南 - 双胞胎登记处提取。用贝克抑郁症症状（BDI）测量抑郁症状。使用C反应蛋白（CRP）和白介素6（IL-6）评估炎症状态；中位数高于CRP和IL-6水平的双胞胎被归类为炎症状态升高。对单个BDI项目进行了因子分析，以提取特定的症状维度（神经治疗，情绪，情感认知）。
患有大都会的受试者的抑郁症状比没有大都会的受试者更具抑郁症状。具有神经治疗特征的抑郁症状更为常见，并且与Mets更加牢固。 BDI总分和每个症状subsore均与炎症生物标志物有关。调整了年龄，教育和吸烟状况后，大都会大都会与BDI总分和神经循环分数显着相关。在进一步调整炎症之后，MetS的系数有所下降，但对于BDI神经循环的subsecore仍然具有统计学意义。在控制MetS时，炎症仍然与BDI MOOD subsecore显着相关。
大都会与较高的抑郁症状相关，主要由神经循环特征为特征。炎症是MetS个体抑郁症状的决定因素之一。
Behavioral alterations, including depression, are frequent in individuals with the metabolic syndrome (MetS). Recent findings suggest that chronic activation of innate immunity may be involved. The objective of this study was to examine the relationship between MetS and depressive symptoms and to elucidate the involvement of inflammation in this relationship. Participants were 323 male twins, with and without MetS and free of symptomatic cardiovascular disease, drawn from the Vietnam-Era-Twin Registry. Depressive symptoms were measured with the Beck-Depression-Inventory (BDI). Inflammatory status was assessed using C-reactive protein (CRP) and interleukin-6 (IL-6); twins with both CRP and IL-6 levels above the median were classified as having an elevated inflammatory status. Factor analysis was performed on individual BDI items to extract specific symptom dimensions (neurovegetative, mood, affective-cognitive). Subjects with MetS had more depressive symptoms than those without. Depressive symptoms with neurovegetative features were more common and more robustly associated with MetS. Both the BDI total score and each symptom subscore were associated with inflammatory biomarkers. After adjusting for age, education and smoking status, the MetS was significantly associated with the BDI total score and the neurovegetative score. After further adjusting for inflammation, the coefficient for MetS decreased somewhat, but remained statistically significant for the BDI neurovegetative subscore. When controlling for the MetS, inflammation remained significantly associated with the BDI mood subscore. The MetS is associated with higher depressive symptomatology characterized primarily by neurovegetative features. Inflammation is one determinant of depressive symptoms in individuals with MetS.
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影响因子：
4.8
作者：
Clément, K;Viguerie, N;Langin, D
通讯作者：
Langin, D
影响因子：
158.5
作者：
Musselman, DL;Lawson, DH;Miller, AH
通讯作者：
Miller, AH
DOI：
10.1375/twin.5.5.476
发表时间：
2002-10-01
期刊：
TWIN RESEARCH
影响因子：
--
作者：
Goldberg, J;Curran, B;Boyko, EJ
通讯作者：
Boyko, EJ
影响因子：
45.3
作者：
Capuron, L;Ravaud, A;Dantzer, R
通讯作者：
Dantzer, R
影响因子：
16.2
作者：
Han, TS;Sattar, N;Haffner, SM
通讯作者：
Haffner, SM