Chemokines, chemokine receptors and renal disease.
Chemokines, chemokine receptors and renal disease.
复制标题
趋化因子、趋化因子受体和肾脏疾病。
DOI：
10.1046/j.1523-1755.1999.00551.x
复制
发表时间：
1999
影响因子：
19.6
通讯作者：
J. Egido
中科院分区：
文献类型：
--
作者：
J. Egido
趋化因子是促炎细胞因子，在白细胞趋化和激活中发挥作用。根据靠近 NH2 末端的一对半胱氨酸残基之间是否存在氨基酸，有两个主要的趋化因子家族，称为 CXC 和 CC1,2。 CXC趋化因子[以白细胞介素8 (IL-8)为原型]作用于参与伤口愈合的中性粒细胞和非造血细胞，而CC趋化因子具有更广泛的作用范围，它们对单核细胞、T和B淋巴细胞、自然杀伤(NK)细胞和树突状细胞有活性，因此它们与肾脏疾病密切相关3。单核细胞和组织巨噬细胞是 CC 趋化因子的丰富来源，通常与从头合成相关。单核细胞趋化蛋白-1 (MCP-1) 和 MCP-2 是刺激单核细胞的主要产物。淋巴细胞是一些趋化因子的来源，特别是 RANTES、巨噬细胞炎症蛋白 1 (MIP-1) 和 MIP-1。内皮细胞、成纤维细胞、上皮细胞和其他肾细胞在适当刺激后也会产生CC趋化因子。趋化因子通过与七个跨膜域 G 偶联受体相互作用发挥作用。到目前为止，已鉴定出 9 个 CC 趋化因子受体（CCR1 至 -9），以及 4 个 CXC 趋化因子受体（CXCR1 至 -4）。趋化因子受体表现出混杂的配体识别模式，并且在白细胞中差异表达和调节1,2。
Chemokines are proinflammatory cytokines that function in leukocyte chemoattraction and activation. There are two major families of chemokines, termed CXC and CC, according to the presence or absence of an amino acid between a pair of cysteine residues near the NH2 terminal1,2. CXC chemokines [of which interleukin-8 (IL-8) is the prototype] act on neutrophils and nonhemopoietic cells involved in wound healing, whereas CC chemokines have a wider spectrum of action and they are active on monocytes, T and B lymphocytes, natural killer (NK) cells and dendritic cells, and they are, therefore, of great relevance in renal disease3. Monocytes and tissue macrophages are rich sources of CC chemokines, usually associated with de novo synthesis. Monocyte chemoattractant protein-1 (MCP-1) and MCP-2 are major products of stimulated monocytes. Lymphocytes are sources of some chemokines, particularly RANTES, macrophage inflammatory protein-1 (MIP-1) and MIP-1. Endothelial cells, fibroblasts, epithelial cells and other kidney cells also produce CC chemokines after appropriate stimuli. Chemokines act through interaction with seven transmembrane domain G-coupled receptors. So far, nine receptors have been identified for the CC chemokines (CCR1 to -9), and four for the CXC chemokines (CXCR1 to -4). Chemokine receptors show a promiscuous pattern of ligand recognition and are differentially expressed and regulated in leukocytes1,2.
DOI：
10.1161/01.atv.18.12.1983
发表时间：
1998-12-01
影响因子：
8.7
作者：
Han, KH;Tangirala, RK;Quehenberger, O
通讯作者：
Quehenberger, O
影响因子：
19.6
作者：
Eitner, F;Cui, Y;Alpers, CE
通讯作者：
Alpers, CE
影响因子：
15.9
作者：
Tesch, GH;Schwarting, A;Kelley, VR
通讯作者：
Kelley, VR