Effects of physical activity on life expectancy with cardiovascular disease
Effects of physical activity on life expectancy with cardiovascular disease
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DOI：
10.1001/archinte.165.20.2355
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发表时间：
2005-11-14
影响因子：
--
通讯作者：
Nusselder, W
中科院分区：
文献类型：
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作者：
Franco, OH;de Laet, C;Nusselder, W
背景：缺乏身体活动是心血管疾病的一个可改变的危险因素。然而，人们对体育活动对预期寿命的影响知之甚少，无论是否患有心血管疾病。我们的目标是计算的后果不同的体力活动水平后，50岁的总寿命和预期寿命与心血管疾病和无cardiovascular diseases.Methods：我们构建了多状态的生命表使用的数据从心脏研究计算的影响，3个水平的体力活动（低，中，高）的人口年龄超过50岁。对于生命表计算，我们使用3个转换的风险比（健康至死亡、健康至疾病、疾病至死亡），并根据年龄、性别、吸烟、任何合并症（癌症、左心室肥大、关节炎、糖尿病、踝关节水肿或肺部疾病），并在随访期开始时进行检查。与那些保持低体力活动水平的人相比，中等和高体力活动水平分别使50岁或50岁以上的男性的总预期寿命延长1.3年和3.7年，无心血管疾病的寿命延长1.1年和3.2年。对于妇女的差异分别为1.5和3.5年的总寿命和1.3和3.3年以上的生活中没有心血管疾病，分别：避免久坐不动的生活方式在成年期不仅可以防止心血管疾病独立于其他危险因素，但也大大延长了总寿命和心血管疾病的预期寿命为男性和女性。在中等水平的身体活动中已经看到了这种效果，并且在更高的活动水平下，无心血管疾病预期寿命的增加是两倍。
Background: Physical inactivity is a modifiable risk factor for cardiovascular disease. However, little is known about the effects of physical activity on life expectancy with and without cardiovascular disease. Our objective was to calculate the consequences of different physical activity levels after age 50 years on total life expectancy and life expectancy with and without cardiovascular disease.Methods: We constructed multistate life tables using data from the Framingham Heart Study to calculate the effects of 3 levels of physical activity (low, moderate, and high) among populations older than 50 years. For the life table calculations, we used hazard ratios for 3 transitions (healthy to death, healthy to disease, and disease to death) by levels of physical activity and adjusted for age, sex, smoking, any comorbidity (cancer, left ventricular hypertrophy, arthritis, diabetes, ankle edema, or pulmonary disease), and examination at start of follow-up period.Results: Moderate and high physical activity levels led to 1.3 and 3.7 years more in total life expectancy and 1.1 and 3.2 more years lived without cardiovascular disease, respectively, for men aged 50 years or older compared with those who maintained a low physical activity level. For women the differences were 1.5 and 3.5 years in total life expectancy and 1.3 and 3.3 more years lived free of cardiovascular disease, respectively.Conclusions: Avoiding a sedentary lifestyle during adulthood not only prevents cardiovascular disease independently of other risk factors but also substantially expands the total life expectancy and the cardiovascular disease-free life expectancy for men and women. This effect is already seen at moderate levels of physical activity, and the gains in cardiovascular disease-free life expectancy are twice as large at higher activity levels.