Cytopathic feline leukemia viruses cause apoptosis in hemolymphatic cells.
Cytopathic feline leukemia viruses cause apoptosis in hemolymphatic cells.
复制标题
细胞病变猫白血病病毒导致血淋巴细胞凋亡。
DOI：
10.1007/978-3-642-79850-4_2
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Neil,JC
中科院分区：
文献类型：
--
作者：
Rojko,JL;Hartke,JR;Cheney,CM;Phipps,AJ;Neil,JC
某些分离的癌逆转录病毒猫白血病病毒（FeLV）对血淋巴细胞有强烈的细胞病变。主要的细胞病变决定因素是由SU包膜糖蛋白gp70编码的。含有C亚群SU gp70基因的分离株特异性诱导血淋巴细胞凋亡，而非成纤维细胞。在体外将猫t细胞暴露于FeLV-C中，首先导致多产的病毒复制，其次是病毒诱导的细胞凝集，最后导致细胞凋亡。这种体外现象可以解释体内病毒血症FeLV-C感染后严重进行性胸腺萎缩和红细胞发育不全。不适当的细胞凋亡诱导也被假设为解释与含有变异包膜基因的FeLV分离株相关的严重胸腺淋巴细胞萎缩和进行性免疫退化。讨论了包膜高变异性（可变区1 [Vr1]和5 [Vr5]）对病毒趋向性、病毒血症诱导、中和抗体产生和细胞致病性的影响。FeLV SU gp70 Vr5中某些潜在的细胞病变因子可能来自复制缺陷、表达不良的内源性FeLV。FeLV TM包膜p15E中其他高度保守的区域也可能影响细胞凋亡诱导。
Certain isolates of the oncoretrovirus feline leukemia virus (FeLV) are strongly cytopathic for hemolymphatic cells. A major cytopathicity determinant is encoded by the SU envelope glycoprotein gp70. Isolates with subgroup C SU gp70 genes specifically induce apoptosis in hemolymphatic cells but not fibroblasts. In vitro exposure of feline T-cells to FeLV-C leads first to productive viral replication, next to virus-induced cell agglutination, and lastly to apogenesis. This in vitro phenomenon may explain the severe progressive thymic atrophy and erythroid aplasia which follow viremic FeLV-C infection in vivo. Inappropriate apoptosis induction has also been hypothesized to explain the severe thymicolymphoid atrophy and progressive immune deterioration associated with isolates of FeLV containing variant envelope genes. The influence of envelope hypervariability (variable regions 1 [Vr1] and 5 [Vr5] on virus tropism, viremia induction, neutralizing antibody development and cytopathicity is discussed. Certain potentially cytopathic elements in FeLV SU gp70 Vr5 may derive from replication-defective, poorly expressed, endogenous FeLVs. Other more highly conserved regions in FeLV TM envelope p15E may also influence apoptosis induction.