Submandibular salivary gland transfer prevents radiation-induced xerostomia
Submandibular salivary gland transfer prevents radiation-induced xerostomia
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DOI：
10.1016/s0360-3016(99)00460-5
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发表时间：
2000-01-01
影响因子：
7
通讯作者：
Coulter, L
中科院分区：
文献类型：
--
作者：
Jha, N;Seikaly, H;Coulter, L
背景：口腔干燥是头颈部肿瘤放射治疗的一个重要并发症。我们假设，在开始放射治疗之前，将一个颌下腺转移到颏下空间，在建议的放射野之外，可以预防口干症。方法：我们正在进行一项前瞻性临床试验，将颌下腺转移作为手术干预的一部分。患者进行了临床随访，唾液流的研究和华盛顿大学的生活quality.Results：我们报告的16例患者谁经历了这个程序的早期结果。7例患者已完成治疗，2例患者目前正在接受放射治疗，2例患者术后无放射治疗指征，2例患者等待开始放射治疗，2例患者术后拒绝治疗。1例患者放弃手术转移。所有转移的唾液腺均位于拟定的辐射野之外，并且功能正常。患者没有抱怨任何口腔干燥症，只有轻微的口腔粘膜炎，有没有手术并发症。结论：手术转移的下颌下唾液腺颏下空间（外辐射场）保留其功能，并防止放射性口腔干燥症的发展。(C)2000 Elsevier Science Inc.
Background: Xerostomia is a significant morbidity of radiation therapy in the management of head and neck cancers. We hypothesized that the surgical transfer of one submandibular salivary gland to submental space, outside the proposed radiation field, prior to starting radiation treatment, would prevent xerostomia,Methods: We are conducting a prospective clinical trial where the submandibular gland is transferred as part of the surgical intervention. The patients are followed clinically, with salivary flow studies and University of Washington quality of life questionnaire.Results: We report early results of 16 patients who have undergone this procedure. Seven patients have finished and 2 patients are currently undergoing radiation treatment, In 2 patients, no postoperative radiation treatment was indicated, Two patients are waiting to start radiation treatment and 2 patients refused treatment after surgery. The surgical transfer was abandoned in 1 patient. All of the transferred salivary glands were positioned outside the proposed radiation fields and were functional. The patients did not complain of any xerostomia and developed only minimal oral mucositis, There were no surgical complications.Conclusions: Surgical transfer of a submandibular salivary gland to the submental space (outside the radiation field) preserves its function and prevents the development of radiation-induced xerostomia. (C) 2000 Elsevier Science Inc.