Claudins and alveolar epithelial barrier function in the lung.
Claudins and alveolar epithelial barrier function in the lung.
复制标题
肺中紧密连接蛋白与肺泡上皮屏障功能
DOI：
10.1111/j.1749-6632.2012.06533.x
复制
发表时间：
2012-06
影响因子：
5.2
通讯作者：
Frank JA
中科院分区：
文献类型：
--
作者：
Frank JA
肺的肺泡上皮构成了与外部环境的独特界面。这种薄屏障必须保持用于气体转移的表面，同时连续暴露于潜在危险的环境刺激。因此，肺泡上皮屏障特性的微小差异可能对疾病易感性或结果产生很大影响。此外，最近的工作已经将注意力集中在肺泡上皮细胞作为几种肺部疾病的中心，包括急性肺损伤和特发性肺纤维化。虽然对肺中紧密连接蛋白的功能和调节知之甚少，但新的证据表明，环境刺激可以影响人类疾病中紧密连接蛋白的表达和肺泡屏障功能。本文综述了近年来对claudins在疾病中肺泡上皮屏障破坏和上皮修复中的作用的认识。
The alveolar epithelium of the lung constitutes a unique interface with the outside environment. This thin barrier must maintain a surface for gas transfer while being continuously exposed to potentially hazardous environmental stimuli. Small differences in alveolar epithelial barrier properties could therefore have a large impact on disease susceptibility or outcome. Moreover, recent work has focused attention on the alveolar epithelium as central to several lung diseases, including acute lung injury and idiopathic pulmonary fibrosis. Although relatively little is known about the function and regulation of claudin tight junction proteins in the lung, new evidence suggests that environmental stimuli can influence claudin expression and alveolar barrier function in human disease. This review considers recent advances in the understanding of the role of claudins in the breakdown of the alveolar epithelial barrier in disease and in epithelial repair.