Selective Increase of Intention-Based Economic Decisions by Noninvasive Brain Stimulation to the Dorsolateral Prefrontal Cortex
Selective Increase of Intention-Based Economic Decisions by Noninvasive Brain Stimulation to the Dorsolateral Prefrontal Cortex
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DOI：
10.1523/jneurosci.3885-14.2015
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发表时间：
2015-02-25
影响因子：
5.3
通讯作者：
Haruno, Masahiko
中科院分区：
文献类型：
--
作者：
Nihonsugi, Tsuyoshi;Ihara, Aya;Haruno, Masahiko
另一个人行动背后的意图和结果的影响是人类经济行为的主要决定因素。然而，人们对这两个系统是否共享一个核心神经计算知之甚少。在这里，我们调查了这两个系统是否是因果分离的大脑中整合计算建模，功能性磁共振成像，和经颅直流电刺激实验在一个新开发的信任游戏任务。我们不仅表明，右背外侧前额叶皮层（DLPFC）的活动与基于意图的经济决策，腹侧纹状体和杏仁核的活动与基于结果的决策相关，而且刺激DLPFC选择性地增强基于意图的决策。这些发现表明，右DLPFC参与了合作决策过程中基于意图的决策的实施。这种皮质和皮质下背景的因果分离可能表明这两个决策系统的进化和发展差异。
The intention behind another's action and the impact of the outcome are major determinants of human economic behavior. It is poorly understood, however, whether the two systems share a core neural computation. Here, we investigated whether the two systems are causally dissociable in the brain by integrating computational modeling, functional magnetic resonance imaging, and transcranial direct current stimulation experiments in a newly developed trust game task. We show not only that right dorsolateral prefrontal cortex (DLPFC) activity is correlated with intention-based economic decisions and that ventral striatum and amygdala activity are correlated with outcome-based decisions, but also that stimulation to the DLPFC selectively enhances intention-based decisions. These findings suggest that the right DLPFC is involved in the implementation of intention-based decisions in the processing of cooperative decisions. This causal dissociation of cortical and subcortical backgrounds may indicate evolutionary and developmental differences in the two decision systems.