Sebaceous gland loss and inflammation in scarring alopecia: A potential role in pathogenesis
Sebaceous gland loss and inflammation in scarring alopecia: A potential role in pathogenesis
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DOI：
10.1016/j.jaad.2010.09.774
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发表时间：
2011-09-01
影响因子：
13.8
通讯作者：
Lyle, Stephen
中科院分区：
文献类型：
--
作者：
Al-Zaid, Tariq;Vanderweil, Stefan;Lyle, Stephen
背景：原发性瘢痕性脱发（SA）是一组起源不明的疾病。提高诊断和治疗能力，需要更好地了解他们的pathogenetic.Objectives：我们试图评估的频率，在SA的皮脂腺损失，并确定的作用，皮脂腺和皮脂腺导管炎症的发病机制SA.Methods：90例标本提交脱发的临床病史，疤痕和非疤痕，进行了审查。结果：SA患者的皮脂腺缺失（平均>53%的卵泡）比非SA患者更常见，
Background: Primary scarring alopecia (SA) comprises a group of disorders with poorly defined origins. Improving diagnostic and therapeutic capabilities requires a better understanding of their pathogenesis.Objectives: We sought to assess the frequency of sebaceous gland loss in SA and to identify the role of sebaceous gland and sebaceous gland duct inflammation in the pathogenesis of SA.Methods: Ninety specimens submitted with a clinical history of alopecia, both scarring and nonscarring, were reviewed. Samples were scored based on sebaceous gland, sebaceous duct, and follicle inflammation.Results: Sebaceous gland loss was much more common in cases of SA (>53% of follicles on average) than non-SA (