Neural networks of information processing in posttraumatic stress disorder: A functional magnetic resonance imaging study
Neural networks of information processing in posttraumatic stress disorder: A functional magnetic resonance imaging study
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DOI：
10.1016/j.biopsych.2005.03.021
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发表时间：
2005-07-15
影响因子：
10.6
通讯作者：
Williams, LM
中科院分区：
文献类型：
--
作者：
Bryant, RA;Felmingham, KL;Williams, LM
背景：神经影像研究报告创伤后应激障碍(PTSD)患者内侧前额叶皮质(特别是前扣带回)减少，但杏仁核对恐惧信号的反应增强。我们研究了PTSD患者的前扣带回-杏仁核异常是否会导致显著的、但与威胁无关的信号。方法：PTSD患者(n=14)和年龄和性别匹配的非创伤对照组(n=14)完成了一种适合1.5T场强的功能性磁共振成像的奇怪的听觉范式。结果：对照组在腹侧扣带回和杏仁体前部网络显示双侧激活，PTSD受试者显示双侧背侧前扣带核和杏仁核相对于非靶点的激活。与对照组相比，PTSD受试者对背侧和吻侧前扣带回和左侧杏仁核靶点的反应增强。全脑分析证实了在这项古怪的任务中，对目标的分布式前额-顶叶反应的预期模式。PTSD患者顶后躯体感觉区的活动增强。结论：我们发现PTSD患者的前扣带回反应增强，与对威胁刺激的活动减少的报道相反，提示后者可能是威胁相关内容加工所特有的。嘴侧和背侧前扣带回、左侧杏仁核和顶后网络对显著的非威胁性刺激的激活可能反映了普遍的高度警惕。
Background: Neuroimaging studies report reduced medial prefrontal cortical (particularly anterior cingulate) but enhanced amygdala response to fear signals in posttraumatic Stress Disorder (PTSD). We investigated whether anterior cingulate-amygdala dysregulation in PTSD would generalize to salient, but nonthreat related signals.Methods: Individuals with PTSD (n = 14) and age and sex-matched nontraumatized controls (n = 14) completed an auditory oddball paradigm adapted to functional magnetic resonance imaging at a 1.5-T field strength.Results: Controls displayed bilateral activation in ventral anterior cingulate and amygdala networks, and PTSD subjects showed bilateral dorsal anterior cingulate and amygdala activation to targets relative to nontargets. Compared to controls, PTSD subjects showed enhanced responses to targets in the dorsal and rostral anterior cingulate, and left amygdala. Whole-brain analyses confirmed the expected pattern of distributed prefrontal-parietal responses to targets in the oddball task. Greater activity in posterior parietal somatosensory regions was observed in PTSD.Conclusions: Our findings of enhanced anterior cingulate responses in PTSD contrast with reports of reduced activity for threat stimuli, suggesting that the latter may be specific to processing of threat-related content. Activation in rostral and dorsal anterior cingulate, left amygdala and posterior parietal networks in response to salient, nonthreatening stimuli may reflect generalized hypervigilance.