LIPID-ACCUMULATION IN THE MYOCARDIUM DURING ACUTE REGIONAL ISCHEMIA IN CATS
LIPID-ACCUMULATION IN THE MYOCARDIUM DURING ACUTE REGIONAL ISCHEMIA IN CATS
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DOI：
10.1016/s0022-2828(85)80077-8
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发表时间：
1985-01-01
影响因子：
5
通讯作者：
LEKVEN, J
中科院分区：
文献类型：
--
作者：
JODALEN, H;STANGELAND, L;LEKVEN, J
在急性局灶性缺血3h的猫心模型上，观察了心肌中脂质物质的积聚。用定量体视学技术对心肌活检的电子显微镜下胞浆中脂滴的体积分数进行分析。通过注射荧光素来识别缺血和正常灌注的心肌，并用标记的微球测量组织血流量。正常心肌仅见少量脂滴。在两种类型的心肌交界处有明显的脂滴积聚，而在缺血心肌中的脂滴积聚较少。冠状动脉结扎3h后，动脉非酯化脂肪酸浓度明显升高。动脉脂肪酸合成甘油三酯增加，或细胞内脂肪重新分布，被认为是急性心肌缺血时脂肪堆积的可能原因。
Accumulation of lipid material in the myocardium was studied in cat hearts with acute regional ischaemia of 3 h duration. The fractional volume of lipid droplets in cytosol was analysed by electron microscopy of myocardial biopsies using a quantitative stereologic technique. Ischaemia and normally perfused myocardium were identified by fluoresceine injection, and tissue blood flow measurements were performed with labelled microspheres. In normal myocardium only small amounts of lipid droplets were found. A marked accumulation of lipid droplets occurred in borderline tissue between the two types of myocardium, whereas lipid accumulation in ischaemia myocardium was less pronounced. The arterial concentration of nonesterified fatty acids was clearly increased during the 3 h coronary artery occlusion period. Increased triglyceride synthesis from arterial fatty acids, or redistribution of intracellular lipids, are suggested as possible explanations for lipid accumulation during acute myocardial ischaemia.