Prototype neural semicircular canal prosthesis using patterned electrical stimulation
Prototype neural semicircular canal prosthesis using patterned electrical stimulation
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DOI：
10.1114/1.293
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发表时间：
2000-05-01
影响因子：
3.8
通讯作者：
Merfeld, DM
中科院分区：
文献类型：
--
作者：
Gong, WS;Merfeld, DM
沿着提出了一个原型半规管假体的设计与初步结果。该设备使用压电振动陀螺仪测量头部的角速度（+/-500度/秒）。利用数字滤波器，该速度被滤波以匹配半规管的动态特性，半规管是前庭系统的生理旋转传感器。该数字滤波信号用于调制电刺激的脉冲速率。通过将脉搏率与角速度相关联的S形查找表，脉搏率在50和250 Hz之间变化;稳态速率为150 Hz。电流源利用这些定时脉冲经由铂电极向支配半规管的神经递送电荷平衡的、阴极优先的、双相的电流脉冲。电力由锂电池提供。DC/DC转换器用于从电池产生调节的+/-5V电源。所有的组件都包含在一个小而轻的尼龙盒中，尺寸约为43 mm x 31 mm x 25 mm，可以安装在动物的头顶上。该装置已在手术植入铂电极的豚鼠中进行了测试，结果表明，假体可以为神经系统提供旋转提示。(C)2000生物医学工程学会。【S0090-6964（00）00405-7】。
The design of a prototype semicircular canal prosthesis is presented along with preliminary results. This device measures angular velocity of the head (+/-500 degrees/s) using a piezoelectric vibrating gyroscope. With a digital filter this velocity is filtered to match the dynamic characteristics of the semicircular canals, which are the physiological rotation sensors of the vestibular system. This digitally filtered signal is used to modulate the pulse rate of electrical stimulation. The pulse rate is varied between 50 and 250 Hz via a sigmoidal lookup table relating pulse rate to angular velocity; the steady-state rate is 150 Hz. A current source utilizes these timing pulses to deliver charge balanced, cathodic-first, biphasic, current pulses to the nerves innervating the semicircular canal via platinum electrodes.. Power is supplied via lithium batteries. dc/dc converters are used to generate regulated +/-5 V supplies from the batteries. All of the components are contained in a small, lightweight, Nylon box measuring roughly 43 mm x 31 mm x 25 mm, which can be mounted on the top of an animal's head. This device has been tested in guinea pigs having surgically implanted platinum electrodes, and the results show that the prosthesis can provide a rotational cue to the nervous system. (C) 2000 Biomedical Engineering Society. [S0090-6964(00)00405-7].