Thermal/pH-sensitive core-shell copolymer latex and its potential for targeting drug carrier application
Thermal/pH-sensitive core-shell copolymer latex and its potential for targeting drug carrier application
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DOI：
10.1016/j.polymer.2005.07.098
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发表时间：
2005-11-14
期刊：
影响因子：
4.6
通讯作者：
Lee, CF
中科院分区：
文献类型：
--
作者：
Lin, CL;Chiu, WY;Lee, CF
本论文以N-异丙基丙烯酰胺(NIPAAm)和壳聚糖为核，以甲基丙烯酸(MAA)和甲酸甲酯(MMA)为壳，研究了一种对温度/pH敏感的核壳共聚物的合成、性能及其作为靶向药物载体的潜在应用。通过改变壳聚糖/NIPAAm的质量比和交联剂的浓度，考察了它们对乳胶粒的粒径、反应速度、Zeta电位、表面官能团和比表面积的影响。研究了这些核壳胶乳在不同pH值缓冲溶液中的溶胀行为和热敏行为。模型药物(咖啡因)可以负载在共聚物颗粒内，并通过传输过程有效地保护其不被释放。这些共聚粒子的温度响应性显著增强了蛋白质的偶联，显示了胶乳在靶向药物载体上的应用潜力。(C)2005爱思唯尔有限公司。保留所有权利。
In this work, the synthesis, properties of a thermal/pH-sensitive core-shell copolymer latex were studied and its potential application as a targeting drug carrier was also investigated, where the crosslinked copolymer of N-isopropylacrylamide (NIPAAm) and chitosan was synthesized by soapless dispersion polymerization as the core, and the copolymer of methacrylic acid (MAA) and methyl metbacrylate (MMA) was prepared as the shell. The weight ratio of chitosan/NIPAAm and the concentration of crosslinking agent in feed had been changed to investigate their effects on the particle size, reaction rate, zeta potential, surface functional groups, and specific surface area of latex particles. The swelling and thermo-sensitive behavior of the film made from these core-shell latexes were also studied under different pH values of buffer solution. The model drug (caffeine) could be loaded inside the copolymer particles and protected from releasing through the transport process effectively. And the thermo-responsive property of these copolymer particles significantly enhanced the protein conjugation that showed the potential of the latex being applied on the targeting drug carrier. (c) 2005 Elsevier Ltd. All rights reserved.