Analysis of age of onset data from case-control family studies
Analysis of age of onset data from case-control family studies
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DOI：
10.2307/2533854
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发表时间：
1998-09-01
期刊：
影响因子：
1.9
通讯作者：
Schwartz, AG
中科院分区：
文献类型：
--
作者：
Li, NZ;Yang, P;Schwartz, AG
来自病例对照家系研究的发病年龄数据经常被用于研究疾病与环境或遗传因素之间的关系。在分析这些数据时，必须考虑家庭内发病年龄的相关性和病例对照抽样设计。在这篇文章中，我们提出了一种参数似然方法来研究疾病风险和协变量之间的关系，考虑到家庭成员之间发病年龄的任何相关性，并在调整了家庭内其他共同协变量后，研究了由于遗传因素引起的疾病发病年龄的家族相关性。该方法提供了一种将亲属疾病发病率与风险因素有关的信息与病例/对照对照中包含的信息相结合的方法，以便更准确地估计推定的风险因素的影响。一个来自肺癌病例对照家族研究的数据集被用来说明该方法。分析表明，吸烟史、被动吸烟史和慢性阻塞性肺病病史与肺癌风险呈正相关，在调整这些危险因素后，几乎没有证据表明肺癌风险存在家族聚集性。
Age of onset data from case-control family studies are frequently used to study the relationship between disease and environmental or genetic factors. Dependence of age of onset within family and case-control sampling designs must be taken into account in analyzing such data. In this paper, we propose a parametric likelihood approach to study the relationship between disease risk and covariates, allowing for any correlations in age of onset of disease between family members and to study the familial association in age of onset of disease due to genetic factors, after adjusting for other shared covariates within the family. The method provides a way to combine the information relating disease incidence to risk factors in relatives with the information contained in the case/control contrasts in order to obtain more precise estimates of the effects of the putative risk factors. A data set from a case-control family study of lung cancer is used to illustrate the method. The analysis indicated that history of smoking, passive smoking, and history of chronic obstructive pulmonary disease are positively associated with lung cancer risk, and that, after adjustment for these risk factors, there is little evidence of familial aggregation in lung cancer risk.