Bayes Factors for Genome-Wide Association Studies: Comparison with P-values
Bayes Factors for Genome-Wide Association Studies: Comparison with P-values
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DOI：
10.1002/gepi.20359
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发表时间：
2009-01-01
影响因子：
2.1
通讯作者：
Wakefield, Jon
中科院分区：
文献类型：
--
作者：
Wakefield, Jon
贝叶斯因子是一种汇总度量，它为关联排序或将关联标记为“显着”提供了 P 值的替代方案。我们描述了一种近似贝叶斯因子，该因子易于使用，并且在样本量较大时适用。我们考虑了先前油效应大小的各种选择，包括那些允许效应大小随标记的次等位基因频率 (MAF) 变化的选项。所有重要的贡献都是对特定项的描述。 previous Thai 在贝叶斯因子和 P 值之间给出了相同的排名，提供了两种方法之间的联系，并使使用 P 值的含义更容易理解。作为值得注意性的汇总衡量标准，P 值很难校准，因为它们的解释取决于石油 MAF，而且最重要的是，取决于石油样本大小。结果是使用 P 值的一致决策过程需要一个阈值 与通常的做法相反，显着性随着样本量的增加而减小。热内特.流行病。 33:79-86, 2009。(C) 2008 Wiley-Liss, Inc.
The Bayes factor is a summary measure that provides an alternative to the P-value for the ranking of associations, or the flagging of associations as -significant". We describe an approximate Bayes factor that is straightforward to use and is appropriate when sample sizes are large. We consider various choices of the prior oil the effect size, including those that allow effect size to vary with the minor allele frequency (MAF) of the marker. All important contribution is the description of a specific prior Thai gives identical rankings between Bayes factors and P-values, providing a link between the two approaches, and allowing the implications of the use of P-values to be more easily understood. As a summary measure of noteworthiness P-values are difficult to calibrate since their interpretation depends oil MAF and, crucially, oil sample size. A consequence is that a consistent decision-making procedure using P-values requires a threshold for significance that reduces with sample size, contrary to common practice. Genet. Epidemiol. 33:79-86, 2009. (C) 2008 Wiley-Liss, Inc.