Cortical activity patterns predict speech discrimination ability
Cortical activity patterns predict speech discrimination ability
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DOI：
10.1038/nn.2109
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发表时间：
2008-05-01
影响因子：
25
通讯作者：
Kilgard, Michael P.
中科院分区：
文献类型：
--
作者：
Engineer, Crystal T.;Perez, Claudia A.;Kilgard, Michael P.
大脑皮层的神经活动可以解释感官知觉的许多方面。对视觉运动和振动触觉加工的广泛心理物理和神经生理学研究表明，皮层神经元的平均放电频率为50-500 ms，与辨别能力密切相关。在这项研究中，我们验证了初级听觉皮层（A1）神经元使用1-10毫秒量级的时间精度来表征转移到大鼠听觉范围的语音的假设。在11个辅音辨别任务中，保留尖峰时间时，神经辨别与行为表现高度相关，消除尖峰时间时，神经辨别与行为表现不相关。这一结果表明，脉冲时间有助于听觉皮层对辅音的表征。
Neural activity in the cerebral cortex can explain many aspects of sensory perception. Extensive psychophysical and neurophysiological studies of visual motion and vibrotactile processing show that the firing rate of cortical neurons averaged across 50-500 ms is well correlated with discrimination ability. In this study, we tested the hypothesis that primary auditory cortex (A1) neurons use temporal precision on the order of 1-10 ms to represent speech sounds shifted into the rat hearing range. Neural discrimination was highly correlated with behavioral performance on 11 consonant-discrimination tasks when spike timing was preserved and was not correlated when spike timing was eliminated. This result suggests that spike timing contributes to the auditory cortex representation of consonant sounds.