Adherence of bacteria to human foreskins.
Adherence of bacteria to human foreskins.
复制标题
细菌粘附在人类包皮上。
DOI：
10.1016/s0022-5347(17)41909-4
复制
发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Roberts,JA
中科院分区：
文献类型：
--
作者：
Fussell,EN;Kaack,MB;Cherry,R;Roberts,JA
来自新生儿的人类包皮的粘膜表面显示出被致病菌定殖的倾向。具有P菌毛和1型菌毛的细菌粘附。然而，疏水相互作用以及静电荷似乎是重要的，在这种粘附是菌毛。由于细菌粘附已被证明是女性患者尿路感染的先兆，因此假设男性患者在疾病开始前也可能需要这种对包皮的粘附。因此，未行包皮环切术的男性患者尿路感染的高发病率与病原菌粘附于包皮粘膜表面的这些发现似乎相关。预防男性新生儿尿路感染和急性肾盂肾炎可能需要包皮环切术或防止细菌粘附于人类包皮。(J.尿，140：997-1001，1988）
The mucosal surface of the human foreskin from newborns shows a propensity to be colonized by pathogenic bacteria. Bacteria with P fimbriae and type 1 fimbriae adhere. However, hydrophobic interaction as well as electrostatic charge appear to be as important in this adherence as are fimbriae. Since bacterial adherence has been shown to precede urinary tract infection in female patients it is assumed that this adherence to the foreskin in male patients also may be necessary before initiation of the disease. The high incidence of urinary tract infection in uncircumcised male patients combined with these findings of adherence of pathogenic bacteria to the mucosal surface of the foreskin, thus, would seem to be related. Prevention of urinary tract infection and acute pyelonephritis in male neonates then may require either circumcision or the prevention of bacterial adherence to the human foreskin. (J. Urol., 140: 997–1001, 1988)