Women with mitochondrial haplogroup N9a are protected against metabolic syndrome
Women with mitochondrial haplogroup N9a are protected against metabolic syndrome
复制标题
DOI：
10.2337/db06-1105
复制
发表时间：
2007-02-01
期刊：
影响因子：
7.7
通讯作者：
Yamada, Yoshiji
中科院分区：
文献类型：
--
作者：
Tanaka, Masashi;Fuku, Noriyuki;Yamada, Yoshiji
为了确定线粒体单倍群是否对代谢综合征具有抵抗力或易感性，我们对1337名日本人进行了大规模的关联研究，其中包括871名代谢综合征患者和466名对照组。代谢综合征的诊断依据修订后的国家胆固醇教育计划成人治疗小组III指南，使用BMI = 25 kg/m(2)作为肥胖的临界值，而不是腰围。测定了线粒体基因组编码区25个多态性的基因型，将单倍型分为10个主要单倍群，即F、B、A、N9a、M7a、M7b、G1、G2、D5和D4。多因素logistic回归分析显示，单倍群N9a与女性代谢综合征耐药性显著相关，优势比（OR）为0.21 （95% CI 0.07-0.58, P = 0.0042）。单倍群G1和D5的女性对代谢综合征更有抵抗力，G1的OR为0.22 (0.06-0.689 P = 0.0129)， D5的OR为0.32 （0.10-0.96,P = 0.0469）。这些结果表明，线粒体单倍群N9a可能是日本女性代谢综合征的保护因素。
To identify mitochondrial haplogroups that confer resistance against or susceptibility to metabolic syndrome, we performed a large-scale association study on 1,337 unrelated Japanese individuals, including 871 subjects with metabolic syndrome and 466 control subjects. Metabolic syndrome was diagnosed according to modified National Cholesterol Education Program Adult Treatment Panel III guidelines, using the cutoff point for obesity as a BMI of >= 25 kg/m(2) instead of waist circumference. The genotypes for 25 polymorphisms in the coding region of the mitochondrial genome were determined, and the haplotypes were classified into 10 major haplogroups, i.e., F, B, A, N9a, M7a, M7b, G1, G2, D5, and D4. Multivariate logistic regression analysis revealed that the haplogroup N9a was significantly associated with resistance against metabolic syndrome in women with an odds ratio (OR) Of 0.21 (95% CI 0.07-0.58, P = 0.0042). Women with haplogroups G1 and D5 tended to be resistant against metabolic syndrome with an OR of 0.22 (0.06-0.689 P = 0.0129) for G1 and with an OR of 0.32 (0.10-0.96, P = 0.0469) for D5, respectively. These results indicate that mitochondrial haplogroup N9a may be a protective factor against metabolic syndrome in Japanese women.