CHARACTERIZATION OF THE PHYSIOLOGICAL PATTERN OF EPISODIC GONADOTROPIN-SECRETION THROUGHOUT THE HUMAN MENSTRUAL-CYCLE
CHARACTERIZATION OF THE PHYSIOLOGICAL PATTERN OF EPISODIC GONADOTROPIN-SECRETION THROUGHOUT THE HUMAN MENSTRUAL-CYCLE
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DOI：
10.1210/jcem-62-6-1136
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发表时间：
1986-06-01
影响因子：
5.8
通讯作者：
CROWLEY, WF
中科院分区：
文献类型：
--
作者：
FILICORI, M;SANTORO, N;CROWLEY, WF
为了描述正常月经周期中促性腺激素脉冲性分泌的特征，我们研究了51个排卵周期中的正常妇女。在卵泡早期、中期和晚期以及黄体早期、中期和晚期，每隔10分钟测量一次血浆促性腺激素浓度，持续20-24小时。使用2种不同的计算机辅助脉搏检测算法分析LH数据系列。LH脉冲间期在卵泡期（FP）从94 ± 1.5 μ g/ml降低到1.5 ± 1.5 μ g/ml。4（.+-. SEM）min至71 . ±.晚期FP组4 min（LFP; P < 0.001）。EFP中LH脉冲频率的估计受到睡眠期间LH分泌减慢的显著影响。在黄体期（LP），LH脉冲间间期从103 ± 103逐渐增加。在早期LP（ELP）中为8分钟至216 . ±.晚期LP组平均39 min（LLP; P < 0.001）。ELP中也出现了与睡眠相关的LH间歇性分泌减慢。EFP中的平均LH脉冲幅度（6.5 ± 0.001）。0.4 mIU/ml）在卵泡中期显著降低（MFP; 5.1 ± 0.001）。0.8 mIU/ml; P < 0.05），并再次被LFP增加（7.2 ± 0.05）。1.2 mIU/ml）。LH脉冲幅度在ELP中最高（14.9 ± 0.001）。1.7 mIU/ml），到黄体中期（MLP）下降到12.2 ± 0.001 IU/ml。2.0 mIU/ml，并通过LLP进一步下降至7.6 ± 0.001。1.1 mIU/ml（P < 0.001 vs. ELP）。在82%的研究中，FSH分泌与LH分泌在0-109 min的时滞内显著相关（P < 0.05）。这些结果表明：1)在EFP和ELP中，LH分泌频率从EFP到MFP和LFP增加。3)在MFP中LH脉冲幅度降低，表明在此阶段雌激素对下丘脑-垂体轴的负反馈增强和/或GnRH分泌减少。4)LH脉冲频率和幅度在LP期间逐渐降低，这与下丘脑-垂体轴暴露于孕酮的持续时间相关。5)LH和FSH的分泌之间存在密切关系，表明这两种促性腺激素是共同的刺激因子。
To characterize the spectrum of pulsatile gonadotropin secretion during the course of the normal menstrual cycle, we studied normal women during 51 ovulatory cycles. Plasma gonadotropin concentrations were measured at 10-min intervals for 20-24 h during the early, mid-, and late follicular phases and the early, mid-, and late luteal phases. LH data series were analyzed using 2 different computer-assisted algorithms for pulse detection. The LH interpulse interval decreased during the follicular phase (FP) from 94 .+-. 4 (.+-. SEM) min in the early FP (EFP) to 71 .+-. 4 min by the late FP (LFP; P < 0.001). The estimation of LH pulse frequency in the EFP was significantly affected by slowing of episodic LH secretion during sleep. In the luteal phase (LP), the LH interpulse interval progressively increased from 103 .+-. 8 min in the early LP (ELP) to 216 .+-. 39 min by the late LP (LLP; P < 0.001). Sleep-associated slowing of episodic LH secretion also occurred in the ELP. The mean LH pulse amplitude in the EFP (6.5 .+-. 0.4 mIU/ml) decreased significantly by the midfollicular phase (MFP; 5.1 .+-. 0.8 mIU/ml; P < 0.05) and increased once again by the LFP (7.2 .+-. 1.2 mIU/ml). LH pulse amplitude was highest in the ELP (14.9 .+-. 1.7 mIU/ml), decreased by the midluteal phase (MLP) to 12.2 .+-. 2.0 mIU/ml, and declined further by the LLP to 7.6 .+-. 1.1 mIU/ml (P < 0.001 vs. ELP). FSH secretion was significantly (P < 0.05) correlated with LH secretion at time lags of 0-109 min in 82% of the studies. These results indicate the following. 1) In the EFP and ELP, the frequency of LH secretion increases from the EFP to MFP and LFP. 3) LH pulse amplitude decreases in the MFP, suggesting enhanced negative feedback of estrogen on the hypothalamic-pituitary axis and/or a decrease in GnRH secretion at this stage. 4) A progressive reduction of LH pulse frequency and amplitude occurs during the LP which is correlated with the duration of exposure of the hypothalamic-pituitary axis to progesterone. 5) A close relationship exists between secretion of LH and FSH, suggesting a common stimulatory factor for both gonadotropins.