CHANGES IN TRABECULAR BONE, HEMATOPOIESIS AND BONE-MARROW VESSELS IN APLASTIC-ANEMIA, PRIMARY OSTEOPOROSIS, AND OLD-AGE - A COMPARATIVE HISTOMORPHOMETRIC STUDY
CHANGES IN TRABECULAR BONE, HEMATOPOIESIS AND BONE-MARROW VESSELS IN APLASTIC-ANEMIA, PRIMARY OSTEOPOROSIS, AND OLD-AGE - A COMPARATIVE HISTOMORPHOMETRIC STUDY
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DOI：
10.1016/8756-3282(87)90015-9
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发表时间：
1987-01-01
期刊：
影响因子：
4.1
通讯作者：
GILG, T
中科院分区：
文献类型：
--
作者：
BURKHARDT, R;KETTNER, G;GILG, T
对不同年龄组正常人的骨活检和尸检样本以及年龄和性别匹配的原发性骨质疏松症和再生障碍性贫血患者的骨活检进行回顾性组织学分析，显示出特征性的年龄依赖性和病理变化，包括骨小梁和造血的萎缩，以及窦和动脉毛细血管室的变化。这些结果表明微血管缺陷在骨质疏松症和再生障碍性贫血的发病机制中可能起作用。
Retrospective histologic analyses of bone biopsies and of post mortem samples from normal persons of different age groups, and of bone biopsies of age- and sex-matched groups of patients with primary osteoporosis and aplastic anemia show characteristic age dependent as well as pathologic changes including atrophy of osseous trabeculae and of hematopoiesis, and changes in the sinusoidal and arterial capillary compartments. These results indicate the possible role of a microvascular defect in the pathogensis of osteoporosis and aplastic anemia.