Analysis of the Serum Levels of Fungi-Specific Immunoglobulin E in Patients with Allergic Diseases
Analysis of the Serum Levels of Fungi-Specific Immunoglobulin E in Patients with Allergic Diseases
复制标题
DOI：
10.1159/000319208
复制
发表时间：
2011-01-01
影响因子：
2.8
通讯作者：
Chiang, Bor-Luen
中科院分区：
文献类型：
--
作者：
Chang, Feng-Ying;Lee, Jyh-Hong;Chiang, Bor-Luen
背景：特应性患者对空气传播的过敏原特别敏感。对真菌过敏原的致敏可能与呼吸道变态反应疾病(RAD)和特应性皮炎(AD)有关。本研究探讨不同真菌变应原的致敏作用与特应性疾病临床表现的关系。方法：我们回顾了2004年至2009年台湾大学医院特应症患者的病历。共有133名特应症患者对台湾地区最常见的三种真菌(白色念珠菌、烟曲霉、产黄青霉)中的至少一种敏感，并纳入研究。将患者分为单纯AD组、单纯RAD组和AD+RAD组。用Logistic回归分析真菌致敏与过敏性疾病的关系。结果：对念珠菌特异性IgE的敏感率为81.2%，其次为曲霉菌(69.2%)和青霉菌(63.2%)。孤立性AD是最常见的诊断方法。单纯性AD患者抗曲霉菌、念珠菌和青霉菌特异性IgE抗体水平最高。Logistic回归分析显示，孤立性AD与念珠菌致敏密切相关[优势比(OR)10.45，95%可信区间(CI)2.37~45.9]。青霉菌(OR 0.34，95%CI 0.13~0.87)和念珠菌(OR 0.30，95%CI 0.10~0.92)的增敏作用与RAD呈负相关。结论：真菌致敏与AD的关系比RAD更密切。我们的结果表明，对真菌变应原的特异性致敏在特应性疾病的发病机制中起着关键作用。版权所有(C)2010 S.Karger AG，巴塞尔
Background: Atopic patients are exceptionally sensitive to airborne allergens. Sensitization to fungal allergens may be associated with respiratory allergic disease (RAD) and atopic dermatitis (AD). This study investigates the relationship between sensitization to different fungal allergens and the clinical manifestations of atopic disease. Methods: We retrospectively reviewed the medical records of atopic patients from the National Taiwan University Hospital from 2004 to 2009. A total of 133 atopic patients were found who were sensitive to at least 1 of the 3 most common fungi (Candida albicans, Aspergillus fumigatus, Penicillium chrysogenum) in Taiwan and were enrolled in the study. These patients were further divided into subgroups of isolated AD, isolated RAD and AD + RAD. The association between sensitization to fungi and allergic disease was analyzed by logistic regression analysis. Results: The sensitization rate to Candida-specific IgE was 81.2%, followed closely by Aspergillus at 69.2% and Penicillium at 63.2%. Isolated AD was the most common diagnosis. The levels of specific IgE antibodies against Aspergillus, Candida and Penicillium were highest in patients with isolated AD. Logistic regression revealed that isolated AD was highly associated with sensitization to Candida [odds ratio (OR) 10.45, 95% confidence interval (CI) 2.37-45.9]. In contrast, sensitization to Penicillium (OR 0.34, 95% CI 0.13-0.87) and Candida (OR 0.30, 95% CI 0.10-0.92) showed a negative association with isolated RAD. Conclusions: Fungal sensitization is more closely associated with AD than RAD. Our results suggest that specific sensitization to fungal allergens plays a critical role in the pathogenesis of atopic disease. Copyright (C) 2010 S. Karger AG, Basel