Quantitative measurements of cerebral blood oxygen saturation using magnetic resonance imaging
Quantitative measurements of cerebral blood oxygen saturation using magnetic resonance imaging
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DOI：
10.1097/00004647-200008000-00008
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发表时间：
2000-08-01
影响因子：
6.3
通讯作者：
Lin, WL
中科院分区：
文献类型：
--
作者：
An, HY;Lin, WL
脑血氧饱和度的定量估计在脑血管疾病的研究中至关重要，因为它可能提供体内组织存活的信息。在目前的研究中，使用了多回波梯度和自旋回波磁共振成像序列来获取8名正常志愿者的图像。所有图像均在西门子1.5T SYMPHONY全身扫描仪(西门子，德国Erlangen)上采集。理论信号模型描述了在脱氧血红蛋白存在下的信号消相现象，用于对采集的图像进行后处理，从而获得活体脑血氧饱和度的定量测量。通过感兴趣的军团分析，所有志愿者的脑实质平均脑血氧饱和度为58.4%+/-1.8%。这与已知的人类正常生理条件下的脑血氧饱和度是非常一致的。虽然还需要进一步的研究来克服影响脑血氧饱和度估计的一些混杂因素：这些初步结果令人鼓舞，应该会为使用磁共振成像方法无创性研究不同病理生理条件下的脑氧代谢开辟一条新的途径。
A quantitative estimate of cerebral blood oxygen saturation is of critical importance in the investigation of cerebrovascular disease because of the fact that it could potentially provide information on tissue viability in vivo. In the current study, a multi-echo gradient and spin echo magnetic resonance imaging sequence was used to acquire images from eight normal volunteer subjects. All images were acquired on a Siemens 1.5T Symphony whole-body scanner (Siemens, Erlangen, Germany). A theoretical signal model, which describes the signal dephasing phenomena in the presence of deoxyhemoglobin, was used for postprocessing of the acquired images and obtaining a quantitative measurement of cerebral blood oxygen saturation in vivo. With a legion-of-interest analysis, a mean cerebral blood oxygen saturation of 58.4% +/- 1.8% was obtained in the brain parenchyma from all volunteers. It is in excellent agreement with the known cerebral blood oxygen saturation under normal physiologic conditions in humans. Although further studies are needed to overcome some of the confounding factors affecting the estimates of cerebral blood oxygen saturation: these preliminary results are encouraging and should open a new avenue for the noninvasive investigation of cerebral oxygen metabolism under different pathophysiologic conditions using a magnetic resonance imaging approach.