Supramolecular hydrogels based on self-assembly between PEO-PPO-PEO triblock copolymers and α-cyclodextrin
Supramolecular hydrogels based on self-assembly between PEO-PPO-PEO triblock copolymers and α-cyclodextrin
复制标题
DOI：
10.1002/jbm.a.31906
复制
发表时间：
2009-03-15
影响因子：
4.9
通讯作者：
Li, Jun
中科院分区：
文献类型：
--
作者：
Ni, Xiping;Cheng, Alan;Li, Jun
本文详细研究了聚环氧乙烷-聚环氧丙烷-聚环氧乙烷（PEO-PPO-PEO）三嵌段共聚物与α-环糊精（α-CD）在水溶液中形成水凝胶的过程。用粘度计研究了该体系的成胶动力学和凝胶流变学性质。溶胶-凝胶相变进行了研究，使用相图，而凝胶化机理进行了研究，采用差示扫描量热分析。结果表明，PEO-PPO-PEO三嵌段共聚物中的PEO链段与α-CD形成包合物，部分形成的包合物进一步自组装形成凝胶。α-CD的加入大大降低了形成凝胶所需的共聚物的浓度。该凝胶具有触变性和可逆性，可能适合用作注射给药系统。(c)2008 Wiley Periodicals，Inc. J Biomed Mater Res 88A：1031-1036，2009
This article reports a detailed study on the hydrogel formation of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) triblock copolymers with alpha-cyclodextrin (alpha-CD) in aqueous solutions. The gelation kinetics and the gel rheological properties were studied using viscometry. The sol-gel phase transitions were studied using phase diagrams, while the gelation mechanism was studied using differential scanning calorimetric analysis. It was concluded that the gelation was induced by the complex formation between the PEO segments of the PEO-PPO-PEO triblock copolymer and alpha-CD, and the further self-assembly of the partially formed inclusion complexes. The addition of alpha-CD largely reduced the concentration of the copolymer needed for get formation. The gels were thixotropic and reversible, and potentially suitable for use as an injectable drug-delivery system. (c) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 88A: 1031-1036, 2009