OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF RETINAL VENOUS OCCLUSION
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF RETINAL VENOUS OCCLUSION
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DOI：
10.1097/iae.0000000000000811
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发表时间：
2015-11-01
影响因子：
3.3
通讯作者：
Puliafito, Carmen A.
中科院分区：
文献类型：
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作者：
Kashani, Amir H.;Lee, Sun Young;Puliafito, Carmen A.
目的：为了非侵入性地评估视网膜微血管在人类受试者与视网膜静脉阻塞使用光学相干断层扫描血管造影术和评估潜在的临床应用程序。方法：这是一个前瞻性的，观察性研究的成年人受试者的临床和影像学结果表明视网膜静脉阻塞。受试者根据其护理标准接受了完整的眼科检查和荧光素血管造影。在原型光谱域-OCTA系统上，在以中央凹和脑旁区域为中心的3 mm x 3 mm和6 mm x 6 mm区域中进行光学相干断层扫描血管造影。在由浅、中和深视网膜组成的三个水平板内评估视网膜血管系统。使用基于强度对比度的算法重建每个切片内的脉管系统，并将其可视化为正面图像。光学相干断层扫描血管造影手动分割，以验证自动分割algorithm.Results的准确性：光学相干断层扫描血管造影能够证明几乎所有的临床相关的研究结果在25例急性和慢性视网膜静脉阻塞。这些结果是一致的临床，解剖，荧光血管造影的结果，包括受损的血管灌注，视网膜萎缩，血管扩张，分流血管，和一些形式的intraretinal edema.Conclusion：光学相干断层扫描血管造影是一种研究方法，产生高分辨率，非侵入性血管造影，定性说明了大多数临床相关的结果在视网膜静脉阻塞。光学相干断层扫描血管造影术与荧光素血管造影术对应良好，并且在许多情况下提供更详细的解剖和血流信息。光学相干断层扫描血管造影术，结合标准的光谱域OCT，至少是同样有效的荧光素血管造影术的评估和管理的黄斑并发症的视网膜静脉阻塞。
Purpose: To noninvasively evaluate the retinal microvasculature in human subjects with retinal venous occlusions using optical coherence tomography angiography and assess potential clinical applications.Methods: This was a prospective, observational study of adult human subjects with clinical and imaging findings demonstrating retinal venous occlusion. Subjects underwent complete ophthalmic examination and fluorescein angiography as appropriate for their standard of care. Optical coherence tomography angiography was performed on a prototype spectral domain-OCTA system in 3 mm x 3 mm and 6 mm x 6 mm regions centered on the fovea and parafoveal areas. Retinal vasculature was assessed within three horizontal slabs consisting of the superficial, middle, and deep retina. The vasculature within each slab was reconstructed using intensity contrast-based algorithms and visualized as en-face images. Optical coherence tomography angiograms were manually segmented to verify the accuracy of the automated segmentation algorithms.Results: Optical coherence tomography angiography was able to demonstrate almost all of the clinically relevant findings in 25 subjects with acute and chronic retinal venous occlusion. These findings were consistent with clinical, anatomic, and fluorescein angiographic findings including areas of impaired vascular perfusion, retinal atrophy, vascular dilation, shunt vessels, and some forms of intraretinal edema.Conclusion: Optical coherence tomography angiography is an investigational method that generates high-resolution, noninvasive angiograms that qualitatively illustrate most of clinically relevant findings in retinal venous occlusion. Optical coherence tomography angiography corresponds well with fluorescein angiograms and in many cases provides more detailed anatomic and blood flow information. Optical coherence tomography angiography, in conjunction with standard spectral domain-OCT, is at least equally as effective as fluorescein angiography for evaluation and management of the macular complications of retinal venous occlusions.