Prognostic significance of cyclin D1 amplification and overexpression in oral squamous cell carcinomas
Prognostic significance of cyclin D1 amplification and overexpression in oral squamous cell carcinomas
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DOI：
10.1016/s1368-8375(03)00048-4
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发表时间：
2003-09-01
期刊：
影响因子：
4.8
通讯作者：
Amagasa, T
中科院分区：
文献类型：
--
作者：
Miyamoto, R;Uzawa, N;Amagasa, T
细胞周期蛋白D1（CCND 1）的扩增和过表达已被报道为几种肿瘤的独立预后指标。为了研究口腔鳞状细胞癌（OSCC）中CCND 1扩增和过表达之间的关联，并确定哪种作为预后指标更可靠，对41例原发性OSCC（26例男性，15例女性;平均年龄; 58.4岁，范围21-89岁）进行了细针穿刺（FNA）活检和免疫组织化学荧光原位杂交（FISH）。13例患者为I期，13例为II期，9例为III期，6例为IV期。CCND 1扩增和过表达分别为31.7%（13/41）和65.9%（27/41）。CCND 1在所有显示CCND 1扩增的病例中过表达。另一方面，CCND 1过表达也在28例（50.0%）中检测到。统计学分析表明，CCND 1过表达与生存率下降之间的相关性未能达到统计学意义，CCND 1扩增和淋巴结状态是独立的预后指标。总之，有必要研究除了CCND 1扩增之外的其他调节CCND 1表达的途径。从目前的研究来看，在OSCC中，CCND 1扩增是比CCND 1过表达更可靠的预后指标。(C)2003爱思唯尔科技有限公司版权所有。
Amplification and overexpression of cyclin D1 (CCND1) have been reported as independent prognostic indicators of several tumors. To investigate the association between CCND1 amplification and overexpression in oral squamous cell carcinomas (OSCCs), and to determine which is more reliable as a prognostic indicator, fluorescence in situ hybridization (FISH) on fine-needle aspiration (FNA) biopsies and immunohistochemistry were performed on 41 primary OSCCs (26 males, 15 females; mean age; 58.4 years, range 21-89 years). Thirteen patients were stage I, 13 were stage II, nine were stage III, and six were stage IV. CCND1 amplification and overexpression was detected in 13 (31.7%) and 27 (65.9%) of 41 cases. CCND1 was overexpressed in all cases showing CCND1 amplification. On the other hand, CCND1 overexpression was also detected in 14 of 28 cases (50.0%) tacked such amplification. Statistical analysis showed that the correlation between CCND1 overexpression and decreased survival just failed to reach statistical significance, and CCND1 amplification and nodal status were independent prognostic indicators. In conclusion, it will be necessary to investigate the other pathways that regulate CCND1 expression besides CCND1 amplification. From the present study, CCND1 amplification is a more reliable prognostic indicator than CCND1 overexpression in OSCCs. (C) 2003 Elsevier Science Ltd. All rights reserved.